基于DNA序列K-tuple分布的一种非序列比对分析
收稿日期: 2009-09-15
修回日期: 2009-12-02
网络出版日期: 2010-05-24
基金资助
回国人员科研启动项目(编号：Z111020834)资助
A new alignment-free sequence analysis based on the distribution of K-tuple
Received date: 2009-09-15
Revised date: 2009-12-02
Online published: 2010-05-24
沈娟，吴文武，解小莉，郭满才，袁志发 . 基于DNA序列K-tuple分布的一种非序列比对分析[J]. 遗传, 2010 , 32(6) : 606 -612 . DOI: 10.3724/SP.J.1005.2010.00606
Based on the distribution of K-tuple in complete genome, a method without doing sequence alignment to infer difference of biological sequence is proposed in this paper. The method can be used to measure the difference of distribution on K-tuple between the native DNA sequences and the corresponding randomized ones. Applied to construct phylogenetic trees of the complete mitochondrial genomes of 26 species of placental mammals, with K increasing, it yields phylogenetic trees of which the classification effect increasingly matches the result widely recognised by the biological field. The final results show that the phylogenetic trees built by this method is more reasonable than by other alignment-free sequence methods.
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