Sp1/Krüppel样因子的研究进展
收稿日期: 2009-09-15
修回日期: 2009-10-27
网络出版日期: 2010-05-24
基金资助
国家自然科学基金项目(编号: 30971673)和中国科学院知识创新工程青年人才领域前沿项目资助
Progress on Sp1-like and Krüppel-like factors
Received date: 2009-09-15
Revised date: 2009-10-27
Online published: 2010-05-24
Sp1/Krüppel样因子(Sp1-like and Krüppel-like factors, Sp1/KLFs)是一组与真核细胞转录调控密切相关的锌指蛋白。Sp1/KLFs的羧基末端高度保守, 含有3个串联的Cys2His2锌指结构, 用于结合DNA; 其氨基末端在不同的家族成员间存在较大差异, 主要是通过结合辅助因子发挥转录调控作用。Sp1/KLFs的表达具有组织、细胞分布以及发育时期的特异性, 它们通过调控多种富含GC或CACCC的启动子的基因的表达, 参与细胞增殖、分化、凋亡和肿瘤发生、发展等多种生理、病理过程。文章综述了Sp1/KLFs的结构特征、作用机制及生物学功能。
关键词： Sp1/Krüppel样因子; 锌指区; 转录调控
熊倩，阮修艳，方向东 . Sp1/Krüppel样因子的研究进展[J]. 遗传, 2010 , 32(6) : 531 -538 . DOI: 10.3724/SP.J.1005.2010.00531
Sp1-like and Krüppel-like factors (Sp1/KLFs) are a family of zinc-finger proteins that are important components of transcriptional machinery in eukaryotic cells. Sp1/KLFs have highly conserved DNA binding domains at the carboxyl terminus that have three tandem zinc-finger motifs. Their amino terminal regions vary greatly and contain transcription regulatory domains that interact with co-regulators. By regulating the expression of a large number of genes containing GC-rich or CACCC promoters in a tissue-, cell- and developmental stage-specific manner, Sp1/KLFs may be involved in many biological processes, including cell proliferation, differentiation, apoptosis and neoplastic transformation. In this arti-cle, we reviewed the structure, molecular mechanisms and biological functions of Sp1/KLFs.
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