Hoxc13属于Hox(Homobox)基因家族Abd-B类成员之一, 与毛囊形成和毛发生长密切相关。毛发结构蛋白KP(角蛋白)和KAP(角蛋白关联蛋白)的表达都受Hoxc13的严格调控, Hoxc13表达水平会直接影响毛发的特性, 对维持毛囊的正常形态也至关重要。文章就Hoxc13的表达水平对毛囊发育和毛发生长的影响及Hoxc13与相关基因的调控进行了综述。
Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.
[1] Schmidt-Ullrich R, Paus R. Molecular principles of hair follicle induction and morphogenesis. Bioessays, 2005, 27(3): 247–261.
[2] Plikus MV, Mayer JA, de la Cruz D, Baker RE, Maini PK, Maxson R, Chuong CM. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature, 2008, 451(7176): 340–344.
[3] Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E. A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell, 2009, 4(2): 155–169.
[4] Rendl M, Lewis L, Fuchs E. Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol, 2005, 3(11): 1910–1924.
[5] Stenn K S, Paus R. Controls of hair follicle cycling . Am Physiol Soc, 2001, 81(1): 449–494.
[6] Alexander A. Hox in hair growth and development. Naturwissenschaften, 2003, 90(5): 193–211.
[7] Jave-Suarez LF, Winter H, Langbein L, Rogers MA, Schweizer J. Hoxc13 is involved in the regulation of hu-man hair keratin gene expression. J Biol Chem, 2002, 277(5): 3718–3726.
[8] Pruett ND, Tkatchenko TV, Jave-Suarez L, Jacobs DF, Potter CS, Tkatchenko AV, Schweizer J, Awgulewitsch A. Krtap16, characterization of a new hair keratin-associated protein (Kap) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. J Biol Chem, 2004, 279(49): 51524–51533.
[9] Plikus MV, Mayer JA, de la Cruz D, Baker RE, Maini PK, Maxson R, Chuong CM. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature, 2008, 451(7176): 1340–345.
[10] 尹俊.内蒙古绒山羊毛囊发育、生长周期及相关基因的研究[学位论文].内蒙古大学, 2004.
[11] Izpisúa-Belmonte JC, Falkenstein H, Dollé P, Renucci A, Duboule D. Murine genes related to the Drosophila Abd-B homeotic genes are sequentially expressed during devel-opment of the posterior part of the body. EMBO J, 1991, 10(8): 2279–2289.
[12] Geng Y, Johnson LF. Lack of an initiator element is re-sponsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter. Mol Cell Biol, 1993, 13(8): 4894–4903.
[13] Sander GR, Powell BC. Structure and expression of the ovine Hoxc-13 gene. Gene, 2004, 327(1): 107–116.
[14] Wu JH, Zhang WG, Li JQ, Yin J, Zhang YJ. Hoxc13 ex-pression pattern in cashmere goat skin during hair follicle developing. Agric Sci China, 2009, 8(4): 101–105.
[15] Duboule D. Hox is in the hair: A break in colinearity? Genes Dev, 1998, 12(1): 1–4, 62.
[16] Godwin AR, Capecchi MR. Hoxc13 mutant mice lack ex-ternal hair. Genes Dev, 1998, 12(1): 11–20.
[17] Potter CS, Peterson RL, Barth JL, Pruett ND, Jacobs DF, Kern MJ, Argraves WS, Sundberg JP, Awgulewitsch A. Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. J Biol Chem, 2006, 281(39): 29245–29255.
[18] Powell BC, Rogers GE. Cyclic hair-loss and regrowthin transgenic mice overexpressing an intermediatefilament gene. EMBO J, 1990, 9(5): 1485–1493.
[19] Tkatchenko AV, Visconti RP, Shang L, Papenbrock T, Pruett ND, Ito T, Ogawa M, Awgulewitsch A. Overexpres-sion of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia. Development, 2001, 128(9): 1547–1558.
[20] Peterson RL, Tkatchenko TV, Pruett ND, Potter CS, Jacobs DF, Awgulewitsch A. Epididymal cysteine-rich secretory protein 1 encoding gene is expressed in murine hair follicles and downregulated in mice overexpressing Hoxc13. J Inves-tig Dermatol Symp Proc, 2005, 10(3): 238–242.
[21] Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of la