综述

一个新的细胞死亡形式: Parthanatos

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  • 东北林业大学生命科学学院发育生物学研究室, 哈尔滨 150040

收稿日期: 2009-11-26

  修回日期: 2010-01-20

  网络出版日期: 2010-09-20

A new form of cell death: Parthanatos

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  • Laboratory of Development Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China

Received date: 2009-11-26

  Revised date: 2010-01-20

  Online published: 2010-09-20

摘要

Parthanatos是发生在中风、帕金森氏病、心力衰竭、糖尿病以及缺血再灌注损伤等疾病中的一种细胞死亡。该死亡是由兴奋性中毒引起的DNA损伤, 进一步导致PARP-1激活而引发的细胞死亡, 又称为PARP-1依赖性细胞死亡。目前关于Parthanatos的研究还处于初期阶段, 对其信号通路的分子机制说法还不统一。文章就Parthanatos分子机制的研究进展进行了综述。

本文引用格式

王连邦,张丽英,单春华 . 一个新的细胞死亡形式: Parthanatos[J]. 遗传, 2010 , 32(9) : 881 -885 . DOI: 10.3724/SP.J.1005.2010.00881

Abstract

Parthanatos is a form of cell death, which often occurs in many diseases such as stroke, Parkinson’s disease, heart attack, diabetes, and ischemia reperfusion injury. In a cell, the activation of PARP-1 caused by excitotoxicity leads to Parthanatos, which is also known as PARP-1-dependent cell death. There are multiple cell signaling pathways involved in the process of Parthanatos, which have not been fully understood. The main focus of this article is underlying molecular mechanisms of Parthanatos.

Key words: Parthanatos; PARP-1; PAR; AIF; cell death

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