Lipin家族主要包括Lipin 1、Lipin 2与Lipin 3等成员, 是第一个能够双向调控机体脂类代谢的关键调节酶, 不但在脂肪代谢中起调节作用, 还在保持正常的外周神经功能、肝脏脂蛋白分泌、细胞形态、生殖性能及能量稳态等方面发挥着重要的生理功能。Lipin家族基因表达的轻微变异可能与艾滋病、胰岛素抵抗、肥胖症、糖尿病以及代谢综合征中的其他疾病相关, 并有可能成为上述临床疾病治疗的新靶点。文章就Lipin的发现、结构特点、表达与调控、生理功能及其与临床疾病的联系等研究成果进行概述。
Lipin family including at least three members Lipin 1, Lipin 2, and Lipin 3 is a critical regulatory enzyme identified recently, which plays dual roles in lipid metabolisms. Lipin family has physiological effects not only on regulating lipid metabalism, but also on maintaining normal peripheral nervous functions, liver lipoprotein secretion, cell morphous, reproductive functions, and energy homeostasis. Since mutations in Lipin gene express may be associated with AIDS, insulin resistance, obesity, diabetes mellitus, and the other diseases of metabolic syndrome, Lipin may be a new useful target in treatment of above-mentioned clinical-related diseases. In this article, we focused on discovery, construction features, expression, regulatory mechanism, and biological functions of Lipin, as well as its correlation research with clinical-related diseases.
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