综述

miRNA及其靶位点多态性的研究进展

展开
  • 1. 西安交通大学医学院生物医学研究实验中心, 环境与疾病相关基因教育部重点实验室, 西安 710061; 2. 西安交通大学医学院免疫学与病原生物学系, 西安 710061; 3. 西安交通大学医学院遗传学与分子生物学系, 环境与疾病相关基因教育部重点实验室, 西安 710061

收稿日期: 2010-01-10

  修回日期: 2010-03-23

  网络出版日期: 2010-11-25

基金资助

国家自然科学基金项目(编号:30872481)和陕西省科技计划项目(No. 2006K09-G7-1)资助

Progress of polymorphism in microRNA and microRNA target sites

Expand
  • 1. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, the Central Laboratory For Biomedical Research, Medical School, Xi’an Jiaotong University, Xi’an 710061, China; 2. Department of Immunology and Microbiology, Medical School, Xi’an Jiaotong University, Xi’an 710061, China; 3. Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education, Department of Genetics and Molecular Biology, Medical School, Xi’an Jiaotong University, Xi’an 710061, China

Received date: 2010-01-10

  Revised date: 2010-03-23

  Online published: 2010-11-25

摘要

微RNA(microRNA, miRNA)是一类进化上保守、长度为21~23 nt的非编码单链小RNA, 参与个体发育、器官形成、细胞增殖、分化和细胞凋亡等生物学过程, 并在其中发挥重要的调节作用。近年来研究发现, miRNA及其靶位点的多态将引起不同类型的疾患。文章主要从miRNA及其靶位点的多态类型, 以及由多态性引起的相关疾病等方面来阐述miRNA的最新进展。

关键词: miRNA; 疾病; 基因多态性

本文引用格式

刘利英,徐纪茹,宋土生,黄辰 . miRNA及其靶位点多态性的研究进展[J]. 遗传, 2010 , 32(11) : 1091 -1096 . DOI: 10.3724/SP.J.1005.2010.01091

Abstract

MicroRNAs (miRNAs), which are evolutionarily well-conserved, 21- to 23-nucleotide-long, small non-coding RNAs, are widely involved in the regulation of multiple biological processes, such as development, organogenesis, cell proliferation, cell differentiation, and apoptosis. Recent studies have shown that polymorphism in miRNAs and their target sites are closely related to various diseases, such as tumor and cardiological diseases. This review introduces recent progresses on polymorphism in microRNAs and their targeting sites and the related diseases.

Key words: microRNAs; polymorphism; disease

参考文献

[1] Mishra PJ, Bertino JR. MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. Pharmacogenomics, 2009, 10(3): 399–416. [2] Horikawa Y, Wood CG, Yang HS, Zhao H, Ye YQ, Gu J, Lin J, Habuchi T, Wu XF. Single nucleotide polymor-phisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res, 2008, 14(23): 7956–7962. [3] Yang HS, Dinney CP, Ye YQ, Zhu Y, Grossman HB, Wu XF. Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res, 2008, 68(7): 2530–2537. [4] Gottwein E, Cai XZ, Cullen BR. A novel assay for viral microRNA function identifies a single nucleotide poly-morphism that affects Drosha processing. J Virol, 2006, 80(11): 5321–5326. [5] Duan RH, Pak CH, Jin P. Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet, 2007, 16(9): 1124–1131. [6] Wu MQ, Jolicoeur N, Li Z, Zhang LH, Fortin Y, L'Abbe D, Yu ZB, Shen SH. Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis, 2008, 29(9): 1710–1716. [7] Mencía Á, Modamio-Høybjør S, Redshaw N, Morín M, Mayo-Merino F, Olavarrieta L, Aguirre LA, del Castillo I, Steel KP, Dalmay T, Moreno F, Moreno-Pelayo MÁ. Mu-tations in the seed region of human miR-96 are responsi-ble for nonsyndromic progressive hearing loss. Nat Genet, 2009, 41(5): 609–613. [8] Li W, Duan R, Kooy F, Sherman SL, Zhou W, Jin P.Germline mutation of microRNA-125a is associated with breast cancer. J Med Genet, 2009, 46(5): 358–360. [9] Pfister S, Remke M, Castoldi M, Bai AHC, Muckenthaler MU, Kulozik A, von Deimling A, Pscherer A, Lichter P, Korshunov A. Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol, 2009, 117(4): 457–464. [10] Bandi N, Zbinden S, Gugger M, Arnold M, Kocher V, Hasan L, Kappeler A, Brunner T, Vassella E.miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer. Cancer Res, 2009, 69(13): 5553–5559. [11] Diederichs S, Haber DA.Sequence variations of microR-NAs in human cancer: alterations in predicted secondary structure do not affect processing. Cancer Res, 2006, 66(12): 6097–6104. [12] Kontorovich T, Levy A, Korostishevsky M, Nir U, Fried-man E. Single nucleotide polymorphisms in miRNA bind-ing sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. Int J Cancer, 2010, 127(3): 589–597. [13] Iorio MV, Visone R, Di Leva G, Donati V, Petrocca F, Casal-ini P, Taccioli C, Volinia S, Liu CG, Alder H, Calin GA, Mé-nard S, Croce CM. MicroRNA signatures in human ovarian cancer. Cancer Res, 2007, 67(18): 8699–8707. [14] Bandres E, Agirre X, Bitarte N, Ramirez N, Zarate R, Roman-Gomez J, Prosper F, Garcia-Foncillas J. Epigenetic regulation of microRNA expression in colorectal cancer. Int J Cancer, 2009, 125(11): 2737–2743. [15] Abelson JF, Kwan KY, O'Roak BJ, Baek DY, Stillman AA, Morgan TM, Mathews CA, Pauls DL, Rasin MR, Gunel M, Davis NR, Ercan-Sencicek AG, Guez DH, Spertus JA, Leckman JF, Dure LS 4th, Kurlan R, Singer HS, Gilbert DL, Farhi A, Louvi A, Lifton RP, Šestan N, State MW. Sequence variants in SLITRK1 are associated with Tou-rette's syndrome. Science, 2005, 310(5746): 317–320. [16] He HL, Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S, Kloos RT, Croce CM, de la Chapelle A. The role of microRNA genes in papillary thyroid carcinoma. Proc Natl Acad Sci USA, 2005, 102(52): 1
文章导航

/