流感病毒先后造成了1918、1957、1968和2009年等多次全球性大流感, 对人类的生命健康和社会生活形成了巨大的威胁。流感病毒的基因组进化研究为揭示病毒致病机理、疫情监测、准备疫苗和研发抗病毒药物提供了巨大的帮助。文章以流感病毒基因组进化机制为核心, 结合与基因组进化密切相关的抗原性和抗药性等表型进化, 对流感病毒基因组进化研究的相关进展予以介绍。

Four influenza virus pandemics occurred since the beginning of the 20th century. In 1918, 1957, 1968 and 2009, this disease threatened human health and social living greatly. The progress in genomic evolution of influenza virus promoted exploring pathogenic mechanism, surveilling epidemic, preparing influenza vaccine and developing anti-virus drugs. Here, we reviewed the progress in genomic evolution of influenza virus that included evolution mechanism, antigenic evolution, and anti-drug.