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组蛋白甲基化修饰效应分子的研究进展

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  • 北京大学医学部生物化学与分子生物学系, 北京 100191

收稿日期: 2010-09-25

  修回日期: 2010-12-20

  网络出版日期: 2011-04-25

基金资助

国家自然科学基金项目(编号:90919030, 30921062)资助

Advances in effector protein of histone methylation

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  • Department of Biochemistry and Molecular Biology, Health Science Center, Peking University, Beijing 100191, China

Received date: 2010-09-25

  Revised date: 2010-12-20

  Online published: 2011-04-25

摘要

作为一种重要的表观遗传学调控机制, 组蛋白甲基化修饰在多种生命过程中发挥了重要的作用。细胞内有多种组蛋白甲基化酶和去甲基化酶共同调节组蛋白的修饰状态, 在组蛋白甲基化状态确定后, 多种效应分子特异的读取修饰信息, 从而参与基因转录调控过程。文章从组蛋白甲基化效应分子的作用机制方面综述了这一领域的研究进展。

本文引用格式

宋博研,朱卫国 . 组蛋白甲基化修饰效应分子的研究进展[J]. 遗传, 2011 , 33(4) : 285 -292 . DOI: 10.3724/SP.J.1005.2011.00285

Abstract

As a significant epigenetic regulation mechanism, histone methylation plays an important role in many biological processes. In cells, there are various histone methyltransferases and histone demethylases working cooperatively to regulate the histone methylation state. Upon histone modification, effector proteins recognize modification sites specifically, and affect gene transcriptional process. This review mainly focuses on recent advances in histone methylation effector protein’s function mechanism.

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