染色体移动复合物主要由蛋白激酶Aurora B、内层着丝粒蛋白、存活蛋白及蛋白Borealin组成。它在细胞分裂的不同阶段, 能及时精确地定位到相关部位并作用于相应底物; 具有调节染色质组蛋白磷酸化, 控制姐妹染色单体的粘着、分离, 参与分裂纺锤体组装及其对染色体的捕捉, 纠正动粒与微管间不适当附着, 将染色体精确分配到子细胞及促进胞浆分离等重要功能。文章简要介绍了染色体移动复合物的结构成分, 在染色体臂部、内层着丝粒及纺锤体中区的定位过程, 及其定位在不同部位的相应功能。
Chromosomal passenger complex (CPC) is mainly composed of a protein kinase Aurora B, inner centromere protein, Survivin, and Borealin. As in different periods of cell division, CPC can localise correctly to relavent destinations in time and interact on its different substrates in the mitotic cell. CPC modulats phosphorylation of histone H3 in chromatin aggregation and controlls cohesion or segregation of sister chromatids. It is involved in assembly of a mitotic spindle and its chromosomes catched. Moreover, CPC corrects attachment errors between kinetochore and microtuble and gives faithfuly chromosomal segregation and promoting cytokinesis. Here, the structure compenants, localization on chromosomal arms, inner centromere and central spindle, and functions in defferent posisions of CPC were briefly descriped.
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