综述

果蝇DNA甲基化研究进展

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  • 陕西师范大学生命科学学院, 西安 710062

收稿日期: 2010-10-19

  修回日期: 2011-02-07

  网络出版日期: 2011-07-25

基金资助

中央高校基本科研业务费专项资金(编号:GK201002042), 和陕西省自然科学基金项目(编号:2007C101)资助

DNA methylation in Drosophila, a review of recent studies

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  • College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China

Received date: 2010-10-19

  Revised date: 2011-02-07

  Online published: 2011-07-25

摘要

DNA甲基化是表观遗传调控的重要机制, 但果蝇很久以来被认为是一种缺乏甲基化的模式生物。近年来才证实果蝇基因组中有5′-甲基胞嘧啶残基的存在, 其DNA甲基化水平在胚胎发育早期达到最高, 总体水平低于脊椎动物及植物。果蝇拥有一个包含dDNMT2和dMBD2/3的简单甲基化修饰系统, 其分别与哺乳动物中的DNMT2家族及MBD2/MBD3蛋白高度同源。果蝇DNA甲基化模式和特点可能随果蝇种类不同而不同。文章对果蝇DNA甲基化特点及其功能研究进展进行了综述。

本文引用格式

郭欣欣,叶海燕,张敏 . 果蝇DNA甲基化研究进展[J]. 遗传, 2011 , 33(7) : 713 -719 . DOI: 10.3724/SP.J.1005.2011.00713

Abstract

DNA methylation is a key mechanism underlying epigenetic regulation. Fruit fly has been considered as a free DNA methylation organism until recently a few studies demonstrated that genomic methylated DNA is prevalent during the early embryonic development; but the overall methylation level in Drosophila is lower than in vertebrates and plants. The putative genomic DNA methylation systerm in Drosophila contains a methyltransferase termed dDNMT2 and a methyl-binding protein dMBD2/3. dDNMT2 shows significant homology to the mammalian methyltransferases DNMT2 family, and dMBD2/3 encodes a protein with distinct homology to mammalian methyl-binding proteins MBD2 and MBD3. Some studies also indicated that methylation pattern varies among different species of Drosophila. This article summarizes the recent progresses in studies of DNA methylation in Drosophila.

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