生命早期社会环境会对人类个体身心健康产生持久的影响已久为人知, 然而要了解生命早期经历(包括来自母亲的关爱行为)与一生的认知和情绪健康之间的因果关系却只能借助于动物模型。文章综述了大鼠母爱行为对子代成年后应对应激的行为和繁育行为的影响及其表观遗传机制, 并就这一模型对于环境因素影响人类身心健康的研究所具有的意义进行了展望。
It has been demonstrated that the social environment early in life has a long lasting effect on the physical and psychological health of the human body. However, understanding of the relationship between early life experiences, such as maternal care behavior, and life-long cognitive and emotional health can only rely on the studies on animal models. In this paper, we summarized the maternal care effects on both defensive responses to stress and reproductive behavior in rat, and explored the possible underling epigenetic mechanisms for these effects. Based on this model, we further investigated the significance of such epigenetic effects on human mental health.
[1] Gourion D, Arseneault L, Vitaro F, Brezo J, Turecki G, Tremblay RE. Early environment and major depression in young adults: a longitudinal study. Psychiatry Res, 2008, 161(2): 170-176.
[2] Lupien SJ, King S, Meaney MJ, McEwen BS. Child’s stress hormone levels correlate with mother’s socioeconomic status and depressive state. Biol Psychiatry, 2000, 48(10): 976-980.
[3] Schore AN. Attachment and the regulation of the right brain. Attach Hum Dev, 2000, 2(1): 23-47.
[4] Agrawal AF, Brodie ED III, Brown J. Parent-offspring co-adaptation and the dual genetic control of maternal care. Science, 2001, 292(5522): 1710-1712.
[5] Repetti RL, Taylor SE, Seeman TE. Risky families: family social environments and the mental and physical health of offspring. Psychol Bull, 2002, 128(2): 330-366.
[6] Halligan SL, Herbert J, Goodyer I, Murray L. Disturbances in morning cortisol secretion in association with maternal postnatal depression predict subsequent depressive symptomatology in adolescents. Biol Psychiatry, 2007, 62(1): 40-46.
[7] Kaplan GA, Turrell G, Lynch JW, Everson SA, Helkala EL, Salonen JT. Childhood socioeconomic position and cognitive function in adulthood. Int J Epidemiol, 2001, 30(2): 256-263.
[8] Wilson RS, Schneider JA, Boyle PA, Arnold SE, Tang Y, Bennett DA. Chronic distress and incidence of mild cognitive impairment. Neurology, 2007, 68(24): 2085-2092.
[9] Gunnar MR, Morison SJ, Chisholm K, Schuder M. Salivary cortisol levels in children adopted from romanian orphanages. Dev Psychopathol, 2001, 13(3): 611-628.
[10] Gunnar MR, Frenn K, Wewerka SS, van Ryzin MJ. Moderate versus severe early life stress: associations with stress reactivity and regulation in 10-12-year-old children. Psychoneuroendocrinology, 2009, 34(1): 62-75.
[11] Nelson CA III, Zeanah CH, Fox NA, Marshall PJ, Smyke AT, Guthrie D. Cognitive recovery in socially deprived young children: the Bucharest Early Intervention Project. Science, 2007, 318(5858): 1937-1940.
[12] Fairbanks LA. Early experience and cross-generational continuity of mother-infant contact in vervet monkeys. Dev Psychobiol, 1989, 22(7): 669-681.
[13] Berman CM. Intergenerational transmission of maternal rejection rates among free-ranging rhesus monkeys. Anim Behav, 1990, 39(2): 329-337.
[14] Fleming AS, Steiner M, Corter C. Cortisol, hedonics, and maternal responsiveness in human mothers. Horm Behav, 1997, 32(2): 85-98.
[15] Champagne FA, Francis DD, Mar A, Meaney MJ. Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol Behav, 2003, 79(3): 359-371.
[16] Shoji H, Kato K. Maternal behavior of primiparous females in inbred strains of mice: a detailed descriptive analysis. Physiol Behav, 2006, 89(3): 320-328.
[17] Myers MM, Brunelli SA, Squire JM, Shindeldecker RD, Hofer MA. Maternal behavior of SHR rats and its relation-ship to offspring blood pressures. Dev Psychobiol, 1989, 22(1): 29-53.
[18] Myers MM, Brunelli SA, Shair HN, Squire JM, Hofer MA. Relationships between maternal behavior of SHR and WKY dams and adult blood pressures of cross-fostered F1 pups. Dev Psychobiol, 1989, 22(1): 55-67.
[19] Francis DD, Szegda K, Campbell G, Martin WD, Insel TR. Epigenetic sources of behavioral differences in mice. Nat Neurosci, 2003, 6(5): 445-446.
[20] Priebe K, Romeo RD, Francis DD, Sisti HM, Mueller A, McEwen BS, Brake WG. Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study. Dev Psychobiol, 2005, 47(4): 398-407.
[21] Meaney MJ. Maternal care, gene expression, and the trans-mission of individual differences in stress reactivity across generations. Annu Rev Neurosci, 2001, 24(1): 1161-1192.
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