综述

MicroRNAs对斑马鱼发育的调控

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  • 1. 东北林业大学生命科学学院, 哈尔滨 150040 2. 中国水产科学研究院黑龙江水产研究所, 农业部水产生物技术重点开放实验室,哈尔滨 150070

收稿日期: 2011-01-26

  修回日期: 2011-04-27

  网络出版日期: 2011-11-25

基金资助

国家高技术研究发展计划(863计划)项目(编号:2009AA10Z105)资助

Regulation of zebrafish development by microRNAs

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  • 1. College of Life Sciences, Northeast Forestry University, Harbin 150040, China 2. Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Harbin 150070 China

Received date: 2011-01-26

  Revised date: 2011-04-27

  Online published: 2011-11-25

摘要

microRNAs(miRNAs)是一类长度约为22nt的非编码小RNA, 从单细胞到多细胞真核生物中都广泛存在, 在进化过程中高度保守, 对动物发育、生理功能及病理过程都具有重要调控作用。斑马鱼(Danio rerio)是现代生物学研究中广泛使用的模式动物, 以斑马鱼为模型研究miRNAs可以揭示miRNAs在脊椎动物中的功能。文章就miRNAs整体缺失对斑马鱼胚胎发育的影响及一些miRNAs在斑马鱼早期发育过程中的调控机制进行了综述, 从而为探索miRNAs在脊椎动物中的功能及鱼类的生产育种提供理论基础。

关键词: microRNAs; 斑马鱼; 发育

本文引用格式

丁雷,闫学春,孙效文,滕春波 . MicroRNAs对斑马鱼发育的调控[J]. 遗传, 2011 , 33(11) : 1179 -1184 . DOI: 10.3724/SP.J.1005.2011.01179

Abstract

MicroRNAs (miRNAs) are a class of non-coding small RNAs at the length about 22nt, which are found in the cells of both unicellular and multicellular eukaryotes, and highly conserved in many processes of biological evolution. miRNAs play important roles in the regulation of animal development, physiological functions, and pathological processes. As a model organism, zebrafish has been widely used in the modern biological researches. The studies on miRNAs in zebrafish are capable of revealing the function of miRNAs in vertebrate. This paper reviews the effects of total miRNA deletion and the individual miRNAs on the embryonic development of zebrafish in order to provide the clues for the functional researches of miRNAs on vertebrate and breeding in fish.

参考文献

[1] Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR, Ruvkun G. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature, 2000, 403(6772): 901-906.
[2] Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science, 2001, 294(5543): 853-858.
[3] Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 2001, 409(6818): 363-366.
[4] Lee Y, Ahn C, Han JJ, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, Kim VN. The nuclear RNase III Drosha initiates microRNA processing. Nature, 2003, 425(6956): 415-419.
[5] Ketting RF, Fischer SEJ, Bernstein E, Sijen T, Hannon GJ, Plasterk RHA. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev, 2001, 15(20): 2654-2659.
[6] Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev, 1999, 13(24): 3191-3197.
[7] Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: dou-blestranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell, 2000, 101(1): 25-33.
[8] Okamura K, Ishizuka A, Siomi H, Siomi MC. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev, 2004, 18(14): 1655-1666.
[9] Pillai RS, Bhattacharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol, 2007, 17(3): 118-126.
[10] Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RHA, Cuppen E. Phylogenetic shadowing and computational identification of human microRNA genes. Cell, 2005, 120(1): 21-24.
[11] Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foà R, Schliwka J, Fuchs U, Novosel A, Müller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M, Weir DB, Choksi R, De Vita G, Frezzetti D, Trompeter HI, Hornung V, Teng G, Hartmann G, Palkovits M, Di Lauro R, Wernet P, Macino G, Rogler CE, Nagle JW, Ju JY, Papavasiliou FN, Benzing T, Lichter P, Tam W, Brownstein MJ, Bosio A, Borkhardt A, Russo JJ, Sander C, Zavolan M, Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell, 2007, 129(7): 1401-1414.
[12] Williams AE. Functional aspects of animal microRNAs. Cell Mol Life Sci, 2008, 65(4): 545-562.
[13] Giraldez AJ, Mishima Y, Rihel J, Grocock RJ, van Dongen S, Inoue K, Enright AJ, Schier AF. Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science, 2006, 312(5770): 75-79.
[14] Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, Bartel DP, Linsley PS, Johnson JM. Microarray analysis shows that some microRNAs downregu-late large numbers of target mRNAs. Nature, 2005, 433 (7027): 769-773.
[15] Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science, 2001, 294(5543): 853-858.
[16] Kloosterman WP, Plasterk RHA. The diverse functions of microRNAs in animal development and disease. Dev Cell, 2006, 11(4): 441-450.
[17] Thatcher EJ, Bond J, Paydar I, Patton JG. Genomic or-ganization of zebrafish microRNAs. BMC Genom-ics, 2008, 9: 253.
[18] Wienholds E, Koudijs MJ, van Eeden FJM, Cuppen E, Plasterk RHA. The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet, 2003, 35(3): 217-218.
[19] Ciruna B, Weidinger G, Knaut H, Thisse B, Thisse C, Raz E, Schier AF. Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proc Natl Acad Sci USA<
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