大多数细胞内都包含靶向不同细胞器的各种运输囊泡, 其运输机制在进化上是高度保守的。Sec1/Munc- 18(SM)蛋白在膜泡运输中起着重要的调控作用,它能够与SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptor)蛋白结合, 共同在细胞内各个膜融合发生部位发挥重要作用。SM蛋白和SNARE复合体中的Syntaxin蛋白结合, 调节SNARE复合体的装配, 并与SNARE协同作用促进整个膜融合过程。文章对SM蛋白在结构和功能分析方面的最新研究进展进行了概述。
Most cells contain various transport vesicles that target to different destinations. The underlying molecular mechanisms are highly conserved in evolution. Sec1/Munc-18 (SM) proteins play an important role on regulating vesicle transport by interacting with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion sites. SM proteins interact with syntaxin, an important component in SNARE complex, to regulate the assembly of SNARE complex, and promote overall membrane fusion process together with SNARE complex. This review summaries new research progresses of structure and function of SM protein.
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