利根川进是一位日本分子生物学家, 由于发现了抗体多样性产生的遗传机制而获得1987年诺贝尔生理学或医学奖; 利根川进还由于研究了学习和记忆的分子与细胞机制而闻名。文章介绍了利根川进的生平和科研情况。
Susumu Tonegawa is a Japanese molecular biologist who won the Nobel Prize for Physiology or Medicine in 1987 for his discovery of "the genetic principle for generation of antibody diversity". Susumu Tonegawa is also famous for his important contributions on neuroscience, who explored the molecular and cellular mechanisms underlying learning and memory. In this article, the life and research on Susumu Tonegawa was introduced.
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[2] Tonegawa S, Hayashi M. Genetic transcription directed by the b2 region of lambda bacteriophage. Proc Natl Acad Sci USA, 1968, 61(4): 1320-1327.
[3] Hozumi N, Tonegawa S. Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA, 1976, 73(10): 3628-3632.
[4] Tonegawa S. That great time in Basel. Cell, 2004, 116(2 Suppl): S99-S101.
[5] Brack C, Hirama M, Lenhard-Schuller R, Tonegawa S. A complete immunoglobulin gene is created by somatic recombination. Cell, 1978, 15(1): 1-14.
[6] Bernard O, Hozumi N, Tonegawa S. Sequences of mouse immunoglobulin light chain genes before and after somatic changes. Cell, 1978, 15(4): 1133-1144.
[7] Lenhard-Schuller R, Hohn B, Brack C, Hirama M, Tonegawa S. DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats. Proc Natl Acad Sci USA, 1978, 75(10): 4709-4713.
[8] Tonegawa S. Somatic generation of antibody diversity. Nature, 1983, 302(5909): 575-581.
[9] 郭晓强. 自动测序仪的发明者——记科学家胡德. 生物学通报, 2005, 40(6): 58-59.
[10] Hayday AC, Diamond DJ, Tanigawa G, Heilig JS, Folsom V, Saito H, Tonegawa S. Unusual organization and diversity of T-cell receptor a-chain genes. Nature, 1985, 316(6031): 828-832.
[11] Silva AJ, Paylor R, Wehner JM, Tonegawa S. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science, 1992, 257(5067): 206-211.
[12] Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell, 1996, 87(7): 1327-1338.
[13] Iwasato T, Datwani A, Wolf AM, Nishiyama H, Taguchi Y, Tonegawa S, Knöpfel T, Erzurumlu RS, Itohara S. Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex. Nature, 2000, 406(6797): 726-731.
[14] http://www.nobelprize.org/nobel_prizes/medicine/laureates/1987/tonegawa.html.
