综述

G蛋白偶联受体3:调控神经系统和卵泡发育的关键因子

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  • 1. 徐州医学院神经生物学教研室, 徐州 221002 2. 南京农业大学动物科学技术学院, 南京 210095

收稿日期: 2012-08-27

  修回日期: 2012-09-26

  网络出版日期: 2013-05-25

基金资助

国家高技术研究发展计划项目(863计划)(编号:2006AA10Z136)资助

G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development

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  • 1. Department of Neurobiology, Xuzhou Medical College, Xuzhou 221002, China 2. College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China

Received date: 2012-08-27

  Revised date: 2012-09-26

  Online published: 2013-05-25

摘要

G蛋白偶联受体(G protein-coupled receptors, GPCRs)是细胞表面最大的受体超家族, 参与调节多种生理和病理过程。G蛋白偶联受体3(G protein-coupled receptor 3, Gpr3)是一种新发现的鞘氨醇1-磷酸受体, 它直接或者间接参与调节脊椎动物神经系统及卵泡的发育过程。作为潜在的治疗多种神经疾病和卵巢早衰的药物靶标, Gpr3的生理功能及作用的分子机制等都值得进一步研究。文章主要就Gpr3及其介导的信号通路在脊椎动物神经系统发育及卵巢卵泡发育过程中的相关作用作一综述。

本文引用格式

张宝乐 高殿帅 徐银学 . G蛋白偶联受体3:调控神经系统和卵泡发育的关键因子[J]. 遗传, 2013 , 35(5) : 578 -586 . DOI: 10.3724/SP.J.1005.2013.00578

Abstract

G protein-coupled receptors (GPCRs), the largest cell surface receptor superfamily, are involved in many physiological and pathological processes. G protein-coupled receptor 3 (Gpr3) is a newly discovered sphingosine 1-phosphate receptor, which directly or indirectly takes part in regulating the processes of nervous system and follicle development in the vertebrates. As a potential therapeutic drug target for a variety of neurological diseases and premature ovarian failure, its physiological function and biological mechanisms deserve further studies. In this paper, we reviewed the functions of Gpr3 in the processes of nervous system development and ovarian follicular development in the vertebrates.

参考文献

[1] Edson MA, Lin YN, Matzuk MM. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology, 2010, 151(1): 358-368.
[2] Goldman RD. Drug-induced gynecomastia in children and adolescents. Can Fam Physician, 2010, 56(4): 344-345.
[3] Islam SK, Hossain KJ, Kamal M, Ahsan M. Serum immunoglobulins and white blood cells status of drug addicts: influence of illicit drugs and sex habit. Addict Biol, 2004, 9(1): 27-33.
[4] Tanaka S, Shaikh IM, Chiocca EA, Saeki Y. The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One, 2009, 4(6): e5922.
[5] Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science, 2009, 323(5916): 946-951.
[6] Valverde O, Célérier E, Baranyi M, Vanderhaeghen P, Maldonado R, Sperlagh B, Vassart G, Ledent C. GPR3 receptor, a novel actor in the emotional-like responses. PLoS One, 2009, 4(3): e4704.
[7] Ruiz-Medina J, Ledent C, Valverde O. GPR3 orphan receptor is involved in neuropathic pain after peripheral nerve injury and regulates morphine-induced antinociception. Neuropharmacology, 2011, 61(1-2): 43-50.
[8] Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, Pendola FL, Knowles BB, Eppig JJ, Jaffe LA. The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science, 2004, 306(5703): 1947-1950.
[9] Ledent C, Demeestere I, Blum D, Petermans J, Hämäläinen T, Smits G, Vassart G. Premature ovarian aging in mice deficient for Gpr3. Proc Natl Acad Sci USA, 2005, 102(25): 8922-8926.
[10] Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T. Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system. FEBS Lett, 1993, 336(2): 317-322.
[11] Iismaa TP, Kiefer J, Liu ML, Baker E, Sutherland GR, Shine J. Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. Genomics, 1994, 24(2): 391-394.
[12] Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, Vassart G, Parmentier M, Libert F. Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem J, 1995, 309(Pt 3): 837-843.
[13] Libert F, Parmentier M, Lefort A, Dinsart C, Van Sande J, Maenhaut C, Simons MJ, Dumont JE, Vassart G. Selective amplification and cloning of four new members of the G protein-coupled receptor family. Science, 1989, 244(4904): 569-572.
[14] Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marçais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL. A whole-genome assembly of the domestic cow, Bos taurus. Genome Biol, 2009, 10(4): R42.
[15] Zhang BL, Ding JH, Li Y, Wang JJ, Zhao YY, Wang W, Shi S, Dong FL, Zhang ZJ, Shi FX, Xu YX. The porcine Gpr3 gene: molecular cloning, characterization and expression level in tissues and cumulus-oocyte complexes during in vitro maturation. Mol Biol Rep, 2012, 39(5): 5831-5839.
[16] Rovati GE, Capra V, Neubig RR. The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. Mol Pharmacol, 2007, 71(4): 959-964.
[17] Aizaki Y, Maruyama K, Nakano-Tetsuka M, Saito Y. Distinct roles of the DRY motif in rat melanin-concentrating hormone receptor 1 in signaling control. Peptides, 2009, 30(5): 974-981.
[18] Song ZH, Modi W, Bonner TI. Molecular cloning and chromosomal localization of human genes enco
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