文章设计了杂交、回交和全同胞交配3个实验, 对美系白色獭兔(♂)和青紫蓝肉兔(♀)杂交所产生的白色蓝眼獭兔突变体的遗传机制进行了等位性测试。结果表明, 白色獭兔蓝眼突变体是维也纳座位(V)发生隐性突变的结果。基因v纯合(vv)对家兔基本毛色基因座(A、B、C、D、E)具有隐性上位作用, 无论其他毛色座位的基因型如何, 只要vv存在即可产生白色蓝眼兔。vv基因型与rr基因型组合即可产生白色蓝眼獭兔。白色蓝眼獭兔突变体在我国家兔育种中是一个新发现, 其遗传机制的阐明, 对獭兔育种和生产具有重要的指导意义。
Using cross, backcross, and full-sib mating experiments, allelism test was conducted to study the genetic mechanism of blue-eyed mutant of the white rex rabbits originated from the F1 generation from the cross American White rex rabbits(♂) × Chinchilla meat rabbits(♀). The study showed that the reason for the blue-eyed mutant of the white rex rabbits was a recessive mutation in Vienna locus. When the V locus was homozygous for the recessive v gene, it was recessive epistatic to other loci (including A, B, C, D, and E), which also controlled the coat color. Regardless of the genotypes in other gene loci, the rabbits appeared blue eyes and white coat color as long as the genotype vv occurred at the Vienna locus. Thus, the combination of genotype vv and genotype rr will produce the blue-eyed and the white rex rabbits. As the blue-eyed mutant of the white rex rabbits is a new finding in China’s rabbit breeding program, it is significant to explain the genetic mechanism of the blue-eyed mutant for the breeding and production of rex rabbits.
[1] Castle WE. Color varieties of the rabbit and of other ro-dents: their origin and inheritance. Science, 1907, 26(661): 287-291.
[2] Punnett RC. Inheritance of coat-colour in rabbits. J Genet, 1912, 2(3): 221-238.
[3] Punnett RC. Further experiments on the inheritance of coat-colour in rabbits. J Genet, 1915, 5(1): 37-50.
[4] Castle WE. Genetics of the Japanese rabbit. J Genet, 1924, 14(2): 225-229.
[5] 徐汉涛, 杭榴玉. 高效益养兔法. 北京: 中国农业出版社, 1997: 76-80.
[6] 常洪. 动物遗传资源学. 北京: 科学出版社, 2009: 254-256.
[7] Barsh G, Cotsarelis G. How hair gets its pigment. Cell, 2007, 130(5): 779-781.
[8] Hofreiter M, Schöneberg T. The genetic and evolutionary basis of colour variation in vertebrates. Cell Mol Life Sci, 2010, 67(15): 2591-2603.
[9] Eiberg H, Mohr J. Assignment of genes coding for brown eye colour (BEY2) and brown hair colour (HCL3) on chromosome 15q. Euro J Hum Genet, 1996, 4(4): 237-241.
[10] Mengel-From J, Wong TH, Morling N, Rees JL, Jackson IJ. Genetic determinants of hair and eye colours in the Scot-tish and Danish populations. BMC Genet, 2009, 10: 88.
[11] Choudhury BP. Visual cortex in the albino rabbit. Exp Brain Res, 1987, 66(3): 565-571.
[12] Hutt FB, Rasmusen A. Animal genetics. 2nd ed. New York: John Wiley & Sons, Inc., 1982: 59-249.
[13] Turner P, Robinson R, Dyet CE. Blue-eyed albino: A new albino allele in the domestic cat. Genetica, 1981, 56(1): 71-73.
[14] Castle WE. Genetics of the Vienna white rabbit. Science, 1922, 55(1419): 269-270.
[15] Castle WE. Genetics of the Vienna white rabbit II. Science, 1922, 55(1425): 429-430.
