组织器官的再生现象一直以来吸引着众多生物学家们的关注。再生能力在不同物种间差异很大, 与人及高等脊椎动物相比, 低等脊椎动物(如：斑马鱼)有着较高的再生能力。斑马鱼的鳍、心脏、视网膜、视神经、脊髓、肝脏及感觉毛细胞等都具有很强的再生能力。因此, 从斑马鱼再生过程的研究中将获得大量有用的信息, 促进对人类再生能力缺陷的认识, 进而推动再生医学的发展。文章就斑马鱼在心脏、神经系统、肝脏、鳍再生医学研究中的进展及应用做一综述。
The phenomenon of “tissue regeneration” has attracted numerous biologists for many years. Regenerative capacity differs greatly across species. The lower vertebrates such as zebrafish have exceptionally high regeneration abilities, while most high vertebrate species including humans do not have a remarkable ability for regeneration. It has been found zebrafish has a strong ability to regenerate a variety of tissues and organs including fins, heart, retina, optic nerve, spinal cord, liver, and sensory hair cells. Thus, we can learn useful information from the zebrafish regeneration model to understand the human regeneration defects and promote the development of regenerative medicine. This review summarizes the current research status for regeneration of heart, nerve, liver, and fin regeneration in zebrafish.
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