MicroRNA对胚胎干细胞的多能性网络调控
收稿日期: 2013-04-01
修回日期: 2013-05-28
网络出版日期: 2013-10-25
基金资助
国家重点基础研究发展计划(973计划)项目(编号：2011CB944202; 2010CB945001)和国家科技支撑计划(编号：2011BAD19B03)资助
The effect of microRNAs on the regulatory network of pluripotency in embryonic stem cells
Received date: 2013-04-01
Revised date: 2013-05-28
Online published: 2013-10-25
白银山 李莉 卫恒习 朱翠 张守全 . MicroRNA对胚胎干细胞的多能性网络调控[J]. 遗传, 2013 , 35(10) : 1153 -1166 . DOI: 10.3724/SP.J.1005.2013.01153
Embryonic stem cells (ESCs) are pluripotent stem cells characterized by their ability to self-renew and their pluripotency to differentiate into all cell types. MicroRNA (miRNA) is a small non-coding RNA molecule which can regulate transcriptional and post-transcriptional gene expression, and may also play significant roles in regulating proliferation and differentiation of ESCs. The maintenance of pluripotency in ESCs may involve a regulatory network of many factors and pathways regulated by miRNA, which includes ESCs transcription factors, cell cycle regulation, epigenetic modifications as well as intracelluar signal transduction. This review mainly elaborates the biogenesis of miRNA, the miRNA families regulating the pluripotency of ESCs, and the effect of miRNA on the regulatory network of pluripotency in ESCs.
Key words： ESCs; miRNA; pluripotency; regulation
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