DNA甲基化异常与肿瘤耐药
收稿日期: 2013-10-22
修回日期: 2014-02-23
网络出版日期: 2014-04-25
基金资助
国家自然科学基金项目(编号：81172091)和江苏省普通高校研究生科研创新计划项目(编号：CXZZ13_0561)资助
Aberrant DNA methylation and drug resistance of tumor cells
Received date: 2013-10-22
Revised date: 2014-02-23
Online published: 2014-04-25
司鑫鑫, 孙玉洁 . DNA甲基化异常与肿瘤耐药[J]. 遗传, 2014 , 36(5) : 411 -419 . DOI: 10.3724/SP.J.1005.2014.0411
Drug resistance is one of the major obstacles limiting the success of cancer chemotherapy. The underlying mechanisms are complex. In recent years, the contribution of epigenetic changes to drug resistance has drawn increasing attention. DNA methylation is an important epigenetic modification that plays an important role in regulating gene expression and maintaining genome stability. Primary or acquired resistance of tumor cells is usually accompanied by aberrant DNA methylation. Accumulating evidence has shown that aberrant DNA methylation is involved in drug resistance of tumor cells. In this review, we briefly review the relationship between DNA methylation and drug resistance of tumor cells as well as the underlying mechanisms.
Key words： cancer drug resistance; DNA methylation; genome stability; gene expression
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