细胞自噬发生的表观遗传调节
收稿日期: 2013-10-22
修回日期: 2014-01-16
网络出版日期: 2014-05-25
基金资助
教育部新世纪优秀人才支持计划(编号：NCET-12-1026)和山东省自然科学杰出青年基金项目(编号：JQ201109)资助
Epigenetic control of autophagy
Received date: 2013-10-22
Revised date: 2014-01-16
Online published: 2014-05-25
细胞自噬是一种进化上保守的, 通过吞噬降解自身大分子物质或细胞器来维持细胞生存的活动。自噬与多种生命活动息息相关, 其功能的紊乱往往会导致肿瘤发生、神经退行性疾病、微生物感染等疾病。研究表明, 表观遗传修饰可以调控细胞自噬的发生, 并在细胞自噬的生物学功能调节过程中发挥重要作用, 但具体调控机制尚需进一步探究。文章综述了细胞自噬发生过程中存在的表观遗传效应, 包括组蛋白乙酰化对细胞自噬激活或抑制的负反馈调控, 通过DNA甲基化调节自噬相关基因活性来影响细胞自噬的发生, miRNA通过靶向调节自噬相关基因表达来影响组蛋白修饰, 从而调控细胞自噬的发生及作用过程等, 旨在为人们进一步研究细胞自噬发生过程中的表观遗传修饰及其机制提供信息依据。
孙源超, 秦训思, 陈宏, 沈伟 . 细胞自噬发生的表观遗传调节[J]. 遗传, 2014 , 36(5) : 447 -455 . DOI: 10.3724/SP.J.1005.2014.0447
Autophagy is an evolutionarily conserved cellular process through cell degradation of own protein aggregates or organelles to survive. Autophagy is closely related to many life activities, and especially, its dysfunctions might cause many diseases and physiological problems, such as tumorigenesis, neurodegeneration and microbial infection. In recent years, many studies found that epigenetic modifications may regulate the occurrence of autophagy and also play an important role in the process of autophgy biological function.However the exact mechanism of epigenetic modifications remains largely unknown. Here,we review the epigenetic effects on regulation of autophagy process, including histone acetylation activation and negatively feedback controlling autophagy, DNA methylation regulating cell autophagy process by changing autophagy related genes, and miRNA regulating autophagy related gene expression by targeted degradation and histone modifications. This review will help understand the relationship between epigenetic effects and autophagy.
Key words： autophagy; epigenetic effects; DNA methylation; histone modification; miRNA
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