SNARE蛋白调控细胞自噬的分子机制
收稿日期: 2013-12-09
修回日期: 2014-01-14
网络出版日期: 2014-05-28
基金资助
国家自然科学基金项目(编号：81372706, 81372235 资助)
Molecular mechanisms of SNARE proteins in regulating autophagy
Received date: 2013-12-09
Revised date: 2014-01-14
Online published: 2014-05-28
陈元渊, 陈红岩, 卢大儒 . SNARE蛋白调控细胞自噬的分子机制[J]. 遗传, 2014 , 36(6) : 547 -551 . DOI: 10.3724/SP.J.1005.2014.0547
Autophagy is a self-protective mechanism that degrades inner and outer invaded substances to sustain self-maintenance. SNARE (Soluble N-ethylmaleimide-sensitive factor attachment protein receptors) hypothesis suggests important roles of SNARE proteins in the cellular activities of substance transport and specific membrane fusion, unveiling the molecular mechanisms of normal and physiological activities within a cell. Since autophagy involves membrane fusions from the birth of autophagosomes to the formation of autolysosomes, we review recent research progress on the roles of SNARE proteins in regulating autophagy.
Key words： autophagy; SNARE hypothesis
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