胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展
收稿日期: 2013-11-05
修回日期: 2014-01-06
网络出版日期: 2014-05-28
基金资助
青岛农业大学高层次人才科研基金(编号：631114)资助
Progress in early pancreas development and reprogramming of terminally differentiated cells into β cells
Received date: 2013-11-05
Revised date: 2014-01-06
Online published: 2014-05-28
曹明君, 董焕生, 潘庆杰, 王红军, 董晓 . 胰腺早期发育及终末分化细胞重编程为胰岛β细胞的研究进展[J]. 遗传, 2014 , 36(6) : 511 -518 . DOI: 10.3724/SP.J.1005.2014.0511
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the immune system attacks insulin-secreting β cells, thus leading to an absolute deficiency of insulin. Patients must rely on exogenous insulin, which cannot effectively prevent diabetes complications. Generation of insulin-secreting cells by reprogramming of pluripotent stem cells or somatic cells is a potential approach for the treatment of T1DM. These cells can be used for cell therapy and drug screening, and may eventually provide a cure for the disease. Significant progress has been made in generating insulin-secreting cells through the expression of β cell specific transcription factors in stem cells or somatic cells. In this review, we summarize recent research progress in early pancreas development, β cell specific transcription factors and reprogramming of terminally differentiated cells into β cells.
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