植物FKBP基因家族的结构及生物学功能
收稿日期: 2013-10-12
修回日期: 2013-12-09
网络出版日期: 2014-05-28
基金资助
转基因生物新品种培育科技重大专项(编号：2013ZX08003-001), 山东省自然科学基金项目(编号：ZR2013CQ036), 山东省现代农业产业技术体系建设经费(编号：SDAIT-01-022-04)和山东省农业生物资源创新利用专项资金资助
Structure and biological functions of plant FKBP family
Received date: 2013-10-12
Revised date: 2013-12-09
Online published: 2014-05-28
FK506结合蛋白(FK506 binding protein, FKBP)是一种在生物体中广泛存在、进化上高度保守的组成型蛋白质。除了作为免疫抑制剂FK506受体以外, FKBP还具有肽脯氨酰顺反异构酶(PPIase)的活性。FKBP在植物中是个大家族, 可作为分子伴侣与一些蛋白相互作用从而调控不同的生化过程。研究表明, 该家族基因在植物的响应胁迫和不同生长发育过程中都扮演着重要角色。最近许多新的FKBP互作蛋白的发现和鉴定表明, FKBP在调控基因表达和光合适应性方面具有广泛的生物学功能。文章对植物FKBP家族的结构特点、分类以及最新的功能研究进展进行了详细的综述。
于彦丽, 李艳娇, 庞凯元, 张发军, 孙琦, 李文才, 孟昭东 . 植物FKBP基因家族的结构及生物学功能[J]. 遗传, 2014 , 36(6) : 536 -546 . DOI: 10.3724/SP.J.1005.2014.0536
FK506-binding proteins (FKBPs) are well known as both the receptor for the immunosuppressant drug FK506 and the prolyl isomerase (PPIase) enzyme. FKBPs are widely and constitutively expressed, and highly conserved during evolution. In higher plants, FKBPs usually form a relative large and diverse family compared with that in other eukaryotes, and serve as important molecular chaperones that interact with specific protein partners to regulate a diversity of cellular processes which mainly influence the plant development and stress responding. More recently, studies discovered a series of new interacting partners of FKBPs, which implicate FKBPs in gene expression regulation and photosynthetic adaptation. This review mainly focuses on the structural characteristics, classification, and the latest discoveries in the physiological functions of FKBPs in higher plants.
Key words： FKBP; structural characteristics; biological functions; immunophilin
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