综述

MicroRNA对皮肤毛囊发育的调控机制

展开
  • 内蒙古农业大学动物科学学院, 动物遗传育种与繁殖自治区重点实验室, 呼和浩特 010018
张璐, 在读硕士研究生, 专业方向:绒山羊育种。E-mail:zl63412732@163.com

收稿日期: 2013-12-03

  网络出版日期: 2014-06-23

基金资助

国家自然科学基金项目(编号:31260539), 国家农业部现代农业产业技术体系项目(编号:CARS-40-05)和国家高技术研究发展计划项目(863计划)(编号:2013AA102506)资助

The regulatory mechanism of microRNAs in skin and hair follicle development

Expand
  • Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

Received date: 2013-12-03

  Online published: 2014-06-23

摘要

MicroRNA是参与转录后水平表达调控的重要因子, 在病理上成为药物作用的潜在靶点, 在生理上成为表型调控的潜在位点。目前, 对于microRNA的功能已有一定了解, 但其在皮肤毛囊发育中的作用机制还不完全清楚。近年来, 高通量测序技术为microRNA的鉴定提供了更准确、快速的途径, 研究发现一些microRNA能够影响皮肤毛囊细胞的分化和增殖, 其相关靶基因在调控毛囊周期性生长的过程中充当重要角色。文章综述了近年来microRNA在皮肤毛囊生长发育调控机制研究领域所取得的成果, 以期为后续开展绒山羊毛囊生长相关microRNA作用机制研究提供借鉴。

本文引用格式

张璐, 张燕军, 苏蕊, 王瑞军, 李金泉 . MicroRNA对皮肤毛囊发育的调控机制[J]. 遗传, 2014 , 36(7) : 655 -660 . DOI: 10.3724/SP.J.1005.2014.0655

Abstract

MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in pathology and potential sites of phenotypic regulation. Although some functions of miRNAs have been known, the regulatory mechanism of miRNAs in skin and hair follicle development remains unclear. High throughput sequencing provides more accurate and rapid method for identification of miRNAs. It has been found that some miRNAs affect the cell differentiation and proliferation of skin and hair follicles, and their target genes play important roles in the periodic growth of hair follicles. In this review, we summarize the recent achievements of the regulatory mechanism of miRNAs in the skin follicles and provide useful clues for further study on miRNA regulation in hair follicle growth of cashmere goat.

参考文献

[1] R, O'Carroll D, Pasolli HA, Zhang ZH, Dietrich FS, Tarakhovsky A, Fuchs E. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet , 2006, 38(3): 356-362.
[2] T, Murchison EP, Liu F, Zhang Y, Yunta-Gonzalez M, Tobias JW, Andl CD, Seykora JT, Hannon GJ, Millar SE. The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol , 2006, 16(10): 1041-1049.
[3] RC, Feinbaum RL, Ambros V, The C. elegansheterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell , 1993, 75(5): 843-854.
[4] BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell , 2003, 115(7): 787-798.
[5] I, Miska EA. MicroRNA functions in animal development and human disease. Development , 2005, 132(21): 4653-4662.
[6] Y, Ahn C, Han J, Choi H, Kim J, Yim J, Lee J, Provost P, Rådmark O, Kim S, Kim VN. The nuclear RNase III Drosha initiates microRNA processing. Nature , 2003, 425(9): 415-419.
[7] Lund E, Guttinger S, Calado A, Dahlberg JE, Kutay U. Nuclear export of microRNA precursors. Science , 2004, 303(5654): 95-98.
[8] Viswanathan SR, Dsley GQ. Lin28: A microrna regulator with a macro role. Cell , 2010, 140(4): 445-449.
[9] 刘志红, 王志新, 赵濛, 俎红丽, 李金泉. miRNA在调控皮肤和毛囊发育中的作用. 遗传, 2013, 35(9): 1087-1094.
[10] I, Ameyar-Zazoua M, Polesskaya A, Ait-Si-Ali S, Groisman R, Souidi M, Cuvellier S, Harel-Bellan A. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol , 2006, 8(3): 278-284.
[11] A, Lian SL, Eystathioy T, Li SQ, Satoh M, Hamel JC, Fritzler MJ, Chan KL. Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol , 2005, 7(12): 1267-1274.
[12] Naguibneva I, Ameyar-Zazoua M, Nonne N, Polesskaya A, Ait-Si-Ali S, Groisman R, Souidi M, Pritchard LL, Harel-Bellan A. An LNA-based loss-of-function assay for micro-RNAs. Biomed Pharmacother , 2006, 60(9): 633-638.
[13] Eder M, Scherr M. MicroRNA and lung cancer. N Engl J Med , 2005, 352(23): 2446-2448.
[14] Varnholt H. The role of microRNAs in primary liver cancer. Ann Hepatol , 2008, 7(2): 104-113.
[15] Nakajima G, Hayashi K, Xi Y, Kudo K, Uchida K, Takasaki K, Yamamoto M, Ju J. Non-coding MicroRNAs hsa-let-7g and hsa-miR-181b are associated with chemoresponse to S-1 in Colon Cancer. Cancer Genomics Pr o teomics , 2006, 3(5): 317-324.
[16] Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu SJ, Schwind S, Santhanam R, Hickey CJ, Becker H, Chandler JC, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Liebhaber SA, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell , 2010, 140(5): 652-665.
[17] S, Zhang Z. Maggot microRNA: A new inhibitory pathway to bacterial infection. Med Hypotheses , 2011, 76(2): 254-255.
[18] 绒山羊皮肤干细胞定位、迁移及次级毛囊生长期差异表达基因文库的构建与筛选[学位论文]. 呼和浩特: 内蒙古农业大学, 2009.
[19] L, Fuchs E. The hair cycle. J Cell Sci , 2006, 119(3): 391-293.
[20] 甘尚权, 杨永林, 张红琳, 宋天增, 冯静, 杨井泉, 高磊, 石国庆, 沈敏. 绵羊ILK基因的克隆及其在毛囊生长期的表达. 遗传, 2012, 34(6): 179-125
[21] 尹俊, 周欢敏. 绒山羊绒毛生长调控机理研究进展. 中国草食动物, 2001, 3(3): 41-44.
[22] MR, Schmidt-Ullrich R, Paus R. The hair follicle as a dynamic miniorgan. Curr Biol , 2009, 19(3): R132-R142.
[23] KS, Paus RP. Controls of hair follicle cycling. Ph y siol Rev , 2001, 81(1): 449-494.
[24] G, Liu R, Li Q, Tang X, Yu M, Li XY, Cao JH, Zhao SH. Identification of microRNAs in wool follicles during Anagen, Catagen, and Telogen Phases in Tibetan Sheep. PLoS ONE , 2013, 8(10): e77801.
[25] C, Wang X, Geng R, He X, Qu L, Chen Y. Discovery of cashmere goat (Capra hircus) microRNAs in skin and hair follicles by Solexa sequencing. BMC Genomics , 2013, 14(7): 511.
[26] ZH, Xiao HM, Li HP, Zhao YH, Lai SY, Yu XL, Cai T
文章导航

/