综合多学科技术手段研究生物体系复杂问题,是目前生物医学研究的显著特征之一,这为本科生教学改革提出了新的更高的要求。噬菌体是开展生命科学研究型教学改革的理想生物材料。文章借鉴美国匹斯堡大学牵头的美国大学生物学教学改革项目“噬菌体猎人”的实践,总结了本课题组近5年来将分枝杆菌噬菌体科研成果转化为本科生命科学研究型教学的经验。
An emerging theme of current biomedical study is a synthesis of multi-disciplinary tools to address the complex biological issues. This trend raised the bar for undergraduate teaching and learning. The phage is an ideal material for teaching reform. Inspired by the “phage hunter” project initiated by Pittsburg University, we present our practice in translating the mycobacteriophage research a chievements into undergraduate teaching experience during the last five years.
[1] MH. Integrative biology: Science for the 21st cent-ury. Bioscience , 2008, 58(4): 349-353.
[2] MH. What is “Integrative Biology”? Integr Comp Biol , 2003, 43(2): 239-241.
[3] G. Integrative biology, an organismic biolog-ist’s point of view. Integr Comp Biol , 2005, 45(2): 330-332.
[4] CM. Systems biology. Chem Eng News , 2003, 81(20): 45-55.
[5] 徐刚标, 曾超珍, 王爱云, 吴若炎. 遗传学与基因组学整合课程探讨. 遗传, 2011, 33(7): 801-806.
[6] GF, Pedulla ML, Jacobs-Sera D, Cichon PM, Foley A, Ford ME, Gonda RM, Houtz JM, Hryckowian AJ, Kel-chner VA, Namburi S, Pajcini KV, Popovich MG, Schle-icher DT, Simanek BZ, Smith AL, Zdanowicz GM, Kumar V, Peebles CL, Jacobs WR Jr, Lawrence JG, Hendrix RW. Exploring the mycobacteriophage metaproteome: phage genomics as an educational platform. PLoS Genet , 2006, 2(6): e92.
[7] TC, Burnett SH, Carson S, Caruso SM, Clase K, DeJong RJ, Dennehy JJ, Denver DR, Dunbar D, Elgin SC, Findley AM, Gissendanner CR, Golebiewska UP, Guild N, Hartzog GA, Grillo WH, Hollowell GP, Hughes LE, Joh-nson A, King RA, Lewis LO, Li W, Rosenzweig F, Rubin MR, Saha MS, Sandoz J, Shaffer CD, Taylor B, Temple L, Vazquez E, Ware VC, Barker LP, Bradley KW, Jacobs- Sera D, Pope WH, Russell DA, Cresawn SG, Lopatto D, Bailey CP, Hatfull GF. A broadly implementable research course in phage discovery and genomics for first-year undergraduate students. MBio , 2014, 5(1): e01051-01013.
[8] XY, Teng TS, Wang HH, Xie JP. Biology of a novel mycobacteriophage, SWU1, isolated from Chinese soil as revealed by genomic characteristics. J Virol , 2012, 86(18): 10230-10231.
[9] XY, Xie LX, Li W, Xie JP. Prophage-like elements present in Mycobacterium genomes. BMC Genomics , 2014, 15(1): 243.
