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人类Y染色体的演化

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  • 1. 内蒙古医科大学附属医院眼科,呼和浩特 010050; 
    2. 内蒙古托克托县人民医院,呼和浩特 010200; 
    3. 内蒙古医科大学基础医学院,呼和浩特 010110
杨仙荣,副主任护师。

收稿日期: 2014-04-03

  网络出版日期: 2014-09-20

基金资助

秦惠莙与李政道中国大学生见习进修基金和国家基金委人才培养基金和国家拔尖人才培养计划资助

The evolution of human Y chromosome

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  • 1. Ophthalmology Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China; 
    2. Tuketuo County People's Hospital, Hohhot 010200, China; 
    3. College of Basic Medicine, Inner Mongolia Medical University, Hohhot 010110, China

Received date: 2014-04-03

  Online published: 2014-09-20

摘要

人类Y染色体由于其性别决定的特殊功能和独有的进化史一直以来都备受关注。Y染色体起源于常染色体,经历了严重的退化过程。由于其缺乏重组,蛋白编码基因少,重复序列多所以研究进展缓慢。近年来,随着比较基因组及测序技术的快速发展,对人类Y染色体最终命运的争论不断加剧,Y染色体的研究正逐步成为热点。文章综述了人类Y染色体的结构、遗传特点、起源及进化过程,并根据目前的研究进展对Y染色体的最终命运进行了讨论,提出了作者的一些看法,以期为从事遗传及性染色体进化的研究者提供参考。

本文引用格式

杨仙荣, 王美琴, 李少华 . 人类Y染色体的演化[J]. 遗传, 2014 , 36(9) : 849 -856 . DOI: 10.3724/SP.J.1005.2014.0849

Abstract

The human Y chromosome is always intriguing for researchers, because of its role in gender determination and its unusual evolutionary history. The Y chromosome evolves from an autosome, and its evolution has been characterized by massive gene decay. The lack of recombination and protein-coding genes and high content of repetitive sequences have hindered the progress in our understanding of the Y chromosome biology. Recently, with the advances in comparative genomics and sequencing technology, the research on Y chromosome has become a hotspot, with an intensified debate about Y-chromosome final destination resulting from degeneration. This review focuses on the structure, inheritance characteristics, gene content, and the origin and evolution of Y chromosome. We also discuss the long-term destiny of Y chromosome.

参考文献

[1] R, Lavranos G, Manolakou P. Sex determination strategies in 2012: towards a common regulatory model. Reprod Biol Endocrin , 2012, 10: 13.
[2] T, Helanterä H. From the origin of sex-determining factors to the evolution of sex-determining systems. Q Rev Biol , 2011, 86(3): 163?180.
[3] T, Schroeder A, Sakata JT, Huang V, Crews D. Segregating variation for temperature-dependent sex determination in a lizard. Heredity , 2010, 106(4): 649?660.
[4] D, Kirkpatrick M, Mank JE, Mcdaniel SF, Pires JC, Rice W, Valenzuela N. Are all sex chromosomes created equal? Trends Genet , 2011, 27(9): 350?357.
[5] JE. Small but mighty: the evolutionary dynamics of W and Y sex chromosomes. Chromosome Res , 2012, 20(1): 21?33.
[6] JA, Heitman J. Evolution of fungal sex chromosomes. Mol Microbiol , 2004, 51(2): 299?306.
[7] K, Tarui H, Toriba M, Yamada K, Nishida-Umehara C, Agata K, Matsuda Y. Evidence for different origin of sex chromosomes in snakes, birds, and mammals and step-wise differentiation of snake sex chro-mosomes. Proc Natl Acad Sci USA , 2006, 103(48): 18190? 18195.
[8] D. Y-chromosome evolution: emerging insights into processes of Y-chromosome degeneration. Nat Rev Genet , 2013, 14(2): 113?124.
[9] BT, Page DC. Functional coherence of the human Y chromosome. Science , 1997, 278(5338): 675?680.
[10] TM, Mendez FL, Meilerman MB, Underhill PA, Zegura SL, Hammer MF. New binary polymorphisms reshape and increase resolution of the human Y chromosomal haplogroup tree. Genome Res , 2008, 18(5): 830? 838.
[11] M, Steinlein C. Sex chromosomes, sex-linked genes, and sex determination in the vertebrate class amp-hibia. EXS , 2001(91): 143?176.
[12] RH, Nagahama Y. Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture , 2002, 208(3?4): 191?364.
[13] JAM. Sex chromosome specialization and degeneration in mammals. Cell , 2006, 124(5): 901?914.
[14] ZY, Moore PH, Ma H, Ackerman CM, Ragiba M, Yu QY, Pearl HM, Kim MS, Charlton JW, Stiles JI, Zee FT, Paterson AH, Ming R. A primitive Y chromosome in papaya marks incipient sex chromosome evolution. Nature , 2004, 427(6972): 348?352.
[15] SP, Pannell JR, Peichel CL, Ashman TL, Charlesworth D, Chippindale AK, Delph LF, Guerrero RF, Scarpino SV, McAllister BF. About PAR: The distinct evolutionary dynamics of the pseudoautosomal region. Trends Genet , 2011, 27(9): 358?367.
[16] PH. Report of the third international workshop on human Y chromosome mapping 1997. Cytogenet Genome Res , 1997, 79(1?2): 1?20.
[17] HJ, Brown WRA, Rappold GA. Hypervariable telomeric sequences from the human sex chromosomes are pseudoautosomal. Nature , 1985, 317(6039): 687?692.
[18] FJ, Svartman M, El-Mogharbel N, Ventura M, Kirby P, Matarazzo MR, Ciccodicola A, Rocchi M, D'Esposito M, Graves JAM. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res , 2003, 13(2): 281?286.
[19] H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature , 2003, 423(6942): 825?837.
[20] S, Skaletsky H, Marszalek JD, Minx PJ, Cordum HS, Waterston RH, Wilson RK, Page DC. Abundant gene conversion between arms of palindromes in human and ape Y chromosomes. Nature , 2003, 423(6942): 873?876.
[21] JF, Skaletsky H, Brown LG, Pyntikova T, Graves T, Fulton RS, Dugan S, Ding Y, Buhay CJ, Kremitzki C, Wang Q, Shen H, Holder M, Villasana D, Nazareth LV, Cree A, Courtney L, Veizer J, Kotkiewicz H, Cho TJ, Koutseva N, Rozen S, Muzny DM
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