高血压易感基因的分子进化
收稿日期: 2014-08-20
网络出版日期: 2014-12-20
基金资助
国家自然科学基金项目(编号：81402747)和浙江省自然科学基金项目(编号：LQ13C060001)资助
The evolutionary study of susceptibility genes for essential hypertension
Received date: 2014-08-20
Online published: 2014-12-20
季林丹, 钱海霞, 徐进 . 高血压易感基因的分子进化[J]. 遗传, 2014 , 36(12) : 1195 -1203 . DOI: 10.3724/SP.J.1005.2014.1195
Genetic studies, including familial linkage analysis, candidate gene approach and genome-wide association study, to some extent, have failed in detecting confirmative susceptibility genes/loci for essential hypertension (EH) in the general population. Previous genetic studies have suggested that differential susceptibility to many metabolic diseases is due to different environmental adaptation patterns during the out-of-Africa expansion, which provides a new strategy for the genetic study of EH. In this review, we introduce the principle and the latest progress of evolutionary study of susceptibility genes for EH. Furthermore, our recent evolutionary screening for EH susceptible genes/loci in Chinese Han population is also summarized. This review is expected to provide useful information for future genetic studies of EH and many other diseases.
Key words： essential hypertension; genetic susceptibility; evolution; adaptation
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