近年来,转录组测序技术在动物重要经济性状受复杂基因网络的调控研究领域取得了显著的成果。作为哺乳动物皮肤的衍生物,毛囊是唯一具有高度自我更新能力、独特的可再生器官,毛囊细胞经增殖分化最终形成毛发。已有的研究表明,诸多生长因子及其受体作为体内分泌协调基因的重要因素,对毛发的生长发育起着重要的调控作用。文章综述了近年来转录组测序技术在人、小鼠及羊等生物的皮肤毛囊发育和再生过程中基因调控方式的研究进展,旨在为今后人工干扰绒毛周期生长发育和分子育种提供理论依据,同时也为皮肤毛囊相关疾病的临床治疗提供新思路。
Recently, transcriptome sequencing technology has achieved significant progresses in gene network regulation of important economic traits in animals. As the derivative of mammalian skin, hair follicle is capable of self-renew. Its proliferation and differentiation result in hair formation. Researches have revealed that many growth factors and receptors coordinate genes and environment, as well as play an extremely important role during hair growth. In this review, we summarize the progresses that transcriptome sequencing technologies have achieved in researches of hair follicle development and renegeration in a variety of species, such as humans, mice, goats. We aim to provide theoretical mechanisms for the artificial interference of villus growth cycle, and new ideas for therapeutic treatment of skin hair follicle- related diseases.
[1] Oro AE, Scott MP. Splitting hairs: dissecting roles of signalling systems in epidermal development. Cell , 1998, 95(5): 575-578.
[2] Hardy MH. The secret life of the hair follicle. Trends Genet , 1992, 8(2): 55-61.
[3] Galbraith H. Fundamental hair follicle biology and fine fibre production in animals. Animal , 2010, 4(9): 1490-1509.
[4] Rogers GE. Biology of the wool follicle: An excursion into a unique tissue interaction system waiting to be re-discovered. Exp Dermatol , 2006, 15(12): 931-949.
[5] 王宁, 荣恩光, 闫晓红. 毛囊发育与毛发生产研究进展. 东北农业大学学报, 2012, 43(9): 6-11.
[6] Yang CC, Cotsarelis G. Review of hair follicle dermal cells. J Dermatol Sci , 2010, 57(1): 2-11.
[7] Lien WH, Polak L, Lin MY, Lay K, Zheng DY, Fuchs E. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators. Nat Cell Biol , 2014, 16(2): 179-190.
[8] Mardaryev AN, Ahmed MI, Vlahov NV, Fessing MY, Gill JH, Sharov AA, Botchkareva NV. Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J , 2010, 24(10): 3869-3881.
[9] Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom A, Chung CY, Cai XQ, Cai CL, Pevny L, Nicolis S, Ma’ayan A, Rendl M. Sox2 in the dermal papilla niche controls hair growth by fine tuning BMP signalling in differentiating hair shaft progenitors. Dev Cell , 2012, 23(5): 981-994.
[10] Hwang J, Mehrani T, Millar SE, Morasso MI. Dlx3 is a crucial regulator of hair follicle differentiation and regeneration. Development , 2008, 135(18): 3149-3159.
[11] Kurek D, Garinis GA, van Doorninck JH, van der Wees J, Grosveld FG. Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles. Development , 2007, 134(2): 261-272.
[12] Keyes BE, Segal JP, Heller E, Lien WH, Chang CY, Guo XY, Oristian DS, Zheng DY, Fuchs E. Nfatc1 orchestrates aging in hair follicle stem cells. Proc Natl Acad Sci USA , 2013, 110(51): E4950-E4959.
[13] 吴萍. Notch信号通路与绒山羊绒毛生长的研究[学位论文]. 呼和浩特: 内蒙古农业大学, 2010.
[14] Pispa J, Pummila M, Barke PA, Thesleff I, Mikkola ML. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet , 2008, 17(21): 3380-3391.
[15] de Schellenberger AA, Horland R, Rosowski M, Paus R, Lauster R, Lindner G. Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles. Exp Dermatol , 2011, 20(4): 361-366.
[16] 蔡婷, 刘志红, 王志新, 赵濛, 俎红丽, 李金泉. miRNA在调控皮肤和毛囊发育中的作用. 遗传, 2013, 35(9): 1087-1094.
[17] Schmidt-Ullrich R, Paus R. Molecular principles of hair follicle induction and morphogenesis. Bioessays , 2005, 27(3):247-261.
[18] Sun FY, Wang JY, Pan QH, Yu YC, Zhang Y, Wan Y, Wang J, Li XY, Hong A. Characterization of function and regulation of miR-24-1 and miR-31. Biochem Biophys Res Commun , 2009, 380(3): 660-665.
[19] Mecklenburg L, Tobin DJ, Muller-Rover S, Handjiski B, Wendt G, Peters EMJ, Pohl S, Moll I, Paus R. Active hair growth (anagen) is associated with angiogenesis. J Invest Dermatol , 2000, 114(5): 909-916.
[20] Pedrioli DML, Karpanen T, Dabouras V, Jurisic G, van de Hoek G, Shin JW, Marino D, Kälin RE, Leidel S, Cinelli P, Schulte-Merker S, Brändli AW, Detmar M. miR-31 functions as a negative regulator of lymphatic vascular lineage-specific differentiation in vitro and vascular development in vivo . Mol Cell Biol , 2010, 30(14): 3620-3634.
[21] Zhu B, Xu T, Yuan JL, Guo XD, Liu DJ. Transcriptome sequencing reveals differences between primary and secondary hair follicle-derived dermal papilla cells of the Cashmere goat ( Capra hircus ). PLoS One , 2013, 8(9): e76282.
[22] Zhang WG, Wang JH, Li JQ, Yashizawa M. A subset of skin-expressed microRNAs with possible roles in goat and sheep hair growth based on expression profiling of mammalian microRNAs. Omics , 2007, 11(4): 385-396.
[23] Yu
