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针对骨髓移植病患中铁过载的去铁治疗研究进展

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  • 1. 江南大学生物工程学院,无锡 214122;
    2. 江南大学无锡医学院,无锡 214122
李士伟,博士生,专业方向:生物制药。E-mail: 289920680@qq.con

收稿日期: 2015-05-06

  修回日期: 2015-07-22

  网络出版日期: 2015-09-20

基金资助

国家自然科学基金面上项目(编号:81470294)资助

Progress of iron-chelating therapy for iron overload in patients after bone marrow transplantation

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  • 1. School of Biotechnology, Jiangnan University, Wuxi 214122, China;
    2.Wuxi Medical School, Jiangnan University, Wuxi 214122, China

Received date: 2015-05-06

  Revised date: 2015-07-22

  Online published: 2015-09-20

摘要

骨髓移植是临床上治疗恶性造血系统疾病的常见手段。而铁过载是临床上常见的并发症之一,对病患的造血功能和治疗后恢复有极大的抑制作用。了解铁过载产生的分子或遗传机制能帮助优化去铁化方案,提高去铁化治疗的效率。本文总结了骨髓移植前后铁过载现象发生机制的最新研究进展,并阐述了临床上多种去铁治疗的方案,以期为该类病患铁过载的预防和治疗提供参考。

本文引用格式

李士伟, 李想, 关锋 . 针对骨髓移植病患中铁过载的去铁治疗研究进展[J]. 遗传, 2015 , 37(9) : 865 -872 . DOI: 10.16288/j.yczz.15-195

Abstract

Bone marrow transplantation (BMT) is commonly used to treat hematopoietic system malignant diseases. Iron overload, which is one of the most common complications in patients undergoing BMT, has a negative impact on survival after allogeneic transplantation. Better understanding of molecular mechanisms of iron overload can improve the treatment regime and improve the efficiency for iron-chelating therapy. In this review, we summarize the mechanisms of iron overload in various conditions and the progression of iron-chelating strategies in patients undergoing BMT. This review will provide insights into the prevention and treatment of patients with iron overload after BMT.

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