非一线抗结核药物耐药机制及耐药性诊断研究进展

刘洋, 王邦兴, 刘志永, 韩轶, 谭耀驹, 李昕洁, 刘健雄, 谭守勇, 张天宇

doi:10.16288/j.yczz.16-138

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2016 , Vol. 38 >Issue 10: 928 - 939

DOI: https://doi.org/10.16288/j.yczz.16-138

综述

非一线抗结核药物耐药机制及耐药性诊断研究进展

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1. 中国科学院广州生物医药与健康研究院,呼吸疾病国家重点实验室,广州 510530;
2. 安徽大学健康科学研究院,合肥 230601;
3. 广州市胸科医院,呼吸疾病国家重点实验室,广州 510095

谭守勇,硕士,主任医师,研究方向：呼吸内科学。张天宇,博士,研究员,研究方向：药学和传染病学。

收稿日期: 2016-04-20

修回日期: 2016-07-14

网络出版日期: 2016-10-20

基金资助

国家自然科学基金项目(编号：81572037),广州市科技计划项目(编号：155700012,201508020248)和呼吸疾病国家重点实验室的开放项目(编号：2014SKLRD-006)资助

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Progress in resistance mechanisms and diagnosis of non-first line anti-TB drugs

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1. State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), Guangzhou 510530, China;
2. Institute of Health Sciences, Anhui University, Hefei 230601, China;
3. Research Division on Tuberculosis, National Key Laboratory on Respiratory Diseases, Guangzhou Chest Hospital, Guangzhou 510095, China

Received date: 2016-04-20

Revised date: 2016-07-14

Online published: 2016-10-20

Supported by

[Supported by the National Natural Science Foundation of China ( No; 81572037),Guangzhou Municipal Clinical Medical Center Program (Nos; 155700012, 201508020248) and the Open Project Grant from the State Key Lab of Respiratory Disease (No; 2014SKLRD-006)]

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摘要

结核病(Tuberculosis, TB)至今仍是世界三大传染疾病之一。2014年,TB导致的死亡人数已经超过HIV。二线抗TB药物是临床治疗耐多药TB(Multidrug-resistant TB, MDR-TB)的主要药物,然而某些MDR-TB患者由于未及时诊断、治疗方案不合理、所处区域医疗条件差等原因,逐渐发展成为广泛耐药TB(Extensively drug-resistant TB, XDR-TB),使治疗更加困难,其死亡率甚至与肺癌接近。目前结核分枝杆菌(Mycobacterium tuberculosis)的耐药性机制研究已经转向非一线药物,如二线、三线和一些新研发的抗TB药物,揭示这些非一线药物的耐药机制对于耐药TB的治疗和新型抗TB药物的研发具有重要意义。本文对目前临床上使用的主要非一线药物的耐药机制研究进行了综述,并对目前常用的TB耐药性诊断方法的优缺点进行了归纳比较。

关键词： 结核病; 结核分枝杆菌; 耐药; 诊断

本文引用格式

刘洋, 王邦兴, 刘志永, 韩轶, 谭耀驹, 李昕洁, 刘健雄, 谭守勇, 张天宇 . 非一线抗结核药物耐药机制及耐药性诊断研究进展[J]. 遗传, 2016 , 38(10) : 928 -939 . DOI: 10.16288/j.yczz.16-138

Abstract

Tuberculosis (TB) is one of the three major infectious diseases in China and all over the world. In 2014, for the first time, TB killed more people than HIV did. Non-first line anti-TB drugs are used as main drugs in the treatment of MDR-TB. However, MDR-TB can gradually develop as extensively drug-resistant TB (XDR-TB) because of poor diagnosis, the unreasonable treatment, poor medical conditions and so on. The death rate of XDR-TB is close to lung cancer. Research on the mechanism of drug resistance of Mycobacterium tuberculosis has turned to non first-line anti-TB drugs: second and third line drugs and some new anti-TB drugs in development. In this review, we summarized the drug resistance mechanisms of the common non-first line anti-TB drugs. Most of drug resistant TB patients can’t get timely diagnosis and correct treatment. So at the end of this article, we also summarized the common methods to diagnose drug-resistant TB.

Key words： tuberculosis; Mycobacterium tuberculosis; drug resistance; diagnosis

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