高通量测序时代下持家基因定义的发展
收稿日期: 2016-11-11
修回日期: 2017-01-24
网络出版日期: 2017-02-10
基金资助
国家自然科学基金项目(31560310,31272416);石河子大学青年教师与名师结对子培养计划项目(SDJDZ201504)
Concept development of housekeeping genes in the high-throughput sequencing era
Received date: 2016-11-11
Revised date: 2017-01-24
Online published: 2017-02-10
Supported by
the National Natural Science Foundation of China(31560310,31272416);the Scholar Pair-training Program of Shihezi University(SDJDZ201504)
魏凯,马磊 . 高通量测序时代下持家基因定义的发展[J]. 遗传, 2017 , 39(2) : 127 -134 . DOI: 10.16288/j.yczz.16-379
Housekeeping genes are typically constitutive genes that are required for the maintenance of basic cellular functions, and are stably expressed in all cells of an organism under all conditions and during all developmental stages. The definition and development of housekeeping genes reflect their essence and characteristics at different times. The present study reviews the concept development of housekeeping genes based on the technologies that quantify gene expression levels. We also analyze pig housekeeping genes by RNA-seq data, and discuss conceptual issues raised by the rapid progress of technologies and the growth of data. Our present study summarizes that housekeeping genes should be defined at different levels, and changing times will witness its conceptual development.
Key words： housekeeping genes; transcriptome sequencing; gene expression
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