Hippo信号通路在乳腺癌中的调控机制及作用
收稿日期: 2017-03-23
修回日期: 2017-04-14
网络出版日期: 2017-06-08
基金资助
国家重点基础研究发展规划(973计划)项目(2015CB910401);国家自然科学基金项目(81430057,81572686)
The regulatory mechanisms and functional roles of the Hippo signaling pathway in breast cancer
Received date: 2017-03-23
Revised date: 2017-04-14
Online published: 2017-06-08
Supported by
the National Basic Research Program of China (973 Program)(2015CB910401);the National Natural Science Foundation of China(81430057,81572686)
姚传波, 周鑫, 陈策实, 雷群英 . Hippo信号通路在乳腺癌中的调控机制及作用[J]. 遗传, 2017 , 39(7) : 617 -629 . DOI: 10.16288/j.yczz.17-100
Hippo signaling pathway has attracted broad attention due to its essential roles in controlling organ size and tumorigenesis. TAZ/YAP, two core downstream molecules of the Hippo signaling pathway in mammals, are tightly regulated by a wide range of extracellular and intrinsic signals in both Hippo signaling pathway-dependent and -independent manners. Besides their roles in the development and function of normal mammary glands, TAZ/YAP display remarkable potency and relevance to multiple aspects of human breast carcinogenesis, including cellular proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition and stemness. In this review, we summarize the regulators of TAZ/YAP, discuss the significant contribution of the Hippo signaling pathway to human breast cancers and highlight their potential therapeutic roles.
Key words： TAZ/YAP; Hippo signaling pathway; breast cancer
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