MicroRNA调控哺乳动物骨骼肌发育
收稿日期: 2017-03-29
修回日期: 2017-09-25
网络出版日期: 2017-12-20
基金资助
国家自然科学基金项目(31672391, 31601920);国家高技术研究发展计划项目(863计划)(2013AA102502)
Advances on microRNA in regulating mammalian skeletal muscle development
Received date: 2017-03-29
Revised date: 2017-09-25
Online published: 2017-12-20
Supported by
the National Natural Science Foundation of China(31672391, 31601920);the National High Technology Research and Development Program of China(2013AA102502)
MicroRNA (miRNA)是一类长度大约为22 bp的小分子非编码RNA,广泛存在于哺乳动物中,部分miRNA表达具有时空和组织特异性。哺乳动物中miRNA主要通过与靶基因3° UTR区结合抑制其翻译,调控机体生物学功能。miRNA在哺乳动物骨骼肌发育中发挥重要调节作用。哺乳动物骨骼肌发育是一个复杂的生物学过程,包括骨骼肌干细胞增殖、迁移、分化,成肌细胞增殖、分化、肌管融合,肌纤维肥大,能量代谢,纤维类型转换等。miRNA参与骨骼肌发育的各个环节,通过靶向各个时期的关键因子调控骨骼肌发育。本文对miRNA在骨骼肌发育中的调控作用进行了综述,以期为深入理解骨骼肌发育规律提供参考。
李新云, 付亮亮, 程会军, 赵书红 . MicroRNA调控哺乳动物骨骼肌发育[J]. 遗传, 2017 , 39(11) : 1046 -1053 . DOI: 10.16288/j.yczz.17-112
MicroRNA (miRNA) is a class of short non-coding RNA, which is about 22 bp in length. In mammals, miRNA exerts its funtion through binding with the 3°-UTR region of target genes and inhibiting their translation. Skeletal muscle development is a complex event, including: proliferation, migration and differentiation of skeletal muscle stem cells; proliferation, differentiation and fusion of myocytes; as well as hypertrophy, energy metabolism and conversion of muscle fiber types. The miRNA plays important roles in all processes of skeletal muscle development through targeting the key factors of different stages. Herein we summarize the miRNA related to muscle development, providing a better understanding of the skeletal muscle development.
Key words： miRNA; skeletal muscle; muscle progenitor cells; satellite cells; myocytes
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