GATA6在肝脏发育中的作用及调控机制
收稿日期: 2017-05-08
修回日期: 2017-12-13
网络出版日期: 2017-12-27
基金资助
国家级大学生创新创业训练计划(201610635068);中央高校基本科研业务费专项资金(XDJK2015B011)
Progress of GATA6 in liver development
Received date: 2017-05-08
Revised date: 2017-12-13
Online published: 2017-12-27
Supported by
the National Undergraduate Innovation and Entrepreneurship Training Program of China(201610635068);Fundamental Research Funds for the Central Universities(XDJK2015B011)
GATA6 (GATA binding protein 6)是GATA锌指转录因子家族成员之一,以其保守的结合基序(G/A)GATA(A/T) 而得名。GATA家族在脊椎动物细胞命运决定与分化、增殖和迁移以及内胚层和中胚层来源的器官发育中具有重要作用。GATA6作为谱系特化因子、染色质重塑因子、多能性因子和“先锋因子”,在内胚层肝脏谱系决定、肝脏特化、肝芽生长以及肝母细胞增殖分化等阶段发挥关键的调控作用。本文综述了GATA6在肝脏发育中的作用及其研究进展,以期为进一步研究 GATA6 等发育关键转录因子的功能及调控机制提供参考。
张玲, 何建波 . GATA6在肝脏发育中的作用及调控机制[J]. 遗传, 2018 , 40(1) : 22 -32 . DOI: 10.16288/j.yczz.17-163
GATA binding protein 6 (GATA6) is a member of the GATA family of zinc-finger transcriptional regulators, whose names come from the conservative base sequence (G/A)GATA(A/T). The GATA families play key roles in cell fate determination, proliferation, migration, and organogenesis of endoderm- and mesoderm-derived organs in vertebrates. As a lineage-specific factor, a chromatin remodeling factor, a pluripotent factor and a pioneer factor, GATA6 is involved in various stages of liver development, including endoderm liver-lineage determination, liver specification, hepatic bud outgrowth and hepatoblast differentiation. In this review, we summarize recent progress in the roles and regulatory mechanisms of GATA6 in liver development.
Key words： GATA6; liver development; transcription factor; pioneer factor; reprogramming
| [1] | Keller T, Thompson CRL. Cell type specificity of a diffusible inducer is determined by a GATA family transcription factor. Development, 2008, 135(9): 1635-1645. | |||
| [2] | Tang YY, Wei YF, He WW, Wang YB, Zhong JN, Qin C. GATA transcription factors in vertebrates: evolutionary, structural and functional interplay. Mol Genet Genomics, 2014, 289(2): 203-214. | |||
| [3] | Molkentin JD. The zinc finger-containing transcription factors GATA-4, -5, and -6: Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem, 2000, 275(50): 38949-38952. | |||
| [4] | Bossard P, Zaret KS. GATA transcription factors as potentiators of gut endoderm differentiation. Development, 1998, 125(24): 4909-4917. | |||
| [5] | Haworth KE, Kotecha S, Mohun TJ, Latinkic BV. GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos. BMC Dev Biol, 2008, 8: 74. | |||
| [6] | Decker K, Goldman DC, Grasch CL, Sussel L. Gata6 is an important regulator of mouse pancreas development. Dev Biol, 2006, 298(2): 415-429. | |||
| [7] | Ko LJ, Engel JD. DNA-binding specificities of the GATA transcription factor family. Mol Cell Biol, 1993, 13(7): 4011-4022. | |||
| [8] | Chen YH, Bates DL, Dey R, Chen PH, Machado ACD, Laird-Offringa IA, Rohs R, Chen L. DNA binding by GATA transcription factor suggests mechanisms of DNA looping and long-range gene regulation. Cell Rep, 2012, 2(5): 1197-1206. | |||
| [9] | Takada K, Obayashi K, Ohashi K, Ohashi-Kobayashi A, Nakanishi-Matsui M, Maeda M. Amino-terminal extension of 146 residues of L-type GATA-6 is required for transcriptional activation but not for self-association. Biochem Biophys Res Commun, 2014, 452(4): 962-966. | |||
| [10] | Wilkins BJ, Pack M. Zebrafish models of human liver development and disease. Compr Physiol, 2013, 3(3): 1213-1230. | |||
| [11] | Adam RM, Mauney JR. GATA6 (GATA binding protein 6). Atlas Genet Cytogenet Oncol Haematol, 2010, 14(12): 1136-1140. | |||
| [12] | Martinelli P, Carrillo-de Santa Pau E, Cox T, Sainz B Jr, Dusetti N, Greenhalf W, Rinaldi L, Costello E, Ghaneh P, Malats N, Büchler M, Pajic M, Biankin AV, Iovanna J, Neoptolemos J, Real FX. GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer. Gut, 2017, 66(9): 1665-1676. | |||
| [13] | Zhao R, Watt AJ, Li JX, Luebke-Wheeler J, Morrisey EE, Duncan SA. GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol, 2005, 25(7): 2622-2631. | |||
| [14] | Bennett J, Wu YG, Gossen J, Zhou P, Stocco C. Loss of GATA-6 and GATA-4 in granulosa cells blocks folliculoge
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