基因编辑技术及其在中国的研究发展
收稿日期: 2018-07-10
修回日期: 2018-09-07
网络出版日期: 2018-09-11
基金资助
国家自然科学基金项目(31430025)
Gene editing technology and its research progress in China
Received date: 2018-07-10
Revised date: 2018-09-07
Online published: 2018-09-11
Supported by
the National Natural Science Foundation of China(31430025)
陈一欧, 宝颖, 马华峥, 伊宗裔, 周卓, 魏文胜 . 基因编辑技术及其在中国的研究发展[J]. 遗传, 2018 , 40(10) : 900 -915 . DOI: 10.16288/j.yczz.18-195
Gene editing is a technology for precision modification of genome sequences or expressing transcripts. Early versions of such techniques include homing endonuclease, zinc finger endonuclease and transcription-like activator effectors. The CRISPR/Cas9 system has recently emerged as a powerful and versatile gene editing tool for a broad spectrum of applications. In this review, we discuss the recent development and applications of gene editing technology, and particularly focus on the progress in China, with the emphasis on mechanistic studies, development of new and extended technologies, the applications in animals, plants and the therapeutics.
Key words： gene editing; genetic engineering; CRISPR; gene function; disease model; gene therapy
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