核糖体DNA转录的表观调控与肿瘤发生
收稿日期: 2018-10-15
修回日期: 2019-01-15
网络出版日期: 2019-02-19
基金资助
国家自然科学基金项目(No. 31671545)
The epigenetic regulation of ribosomal DNA and tumorigenesis
Received date: 2018-10-15
Revised date: 2019-01-15
Online published: 2019-02-19
Supported by
Supported by the National Natural Science Foundation of China(No. 31671545)
程香荣,胡兴琳,姜琦,黄星卫,王楠,雷蕾 . 核糖体DNA转录的表观调控与肿瘤发生[J]. 遗传, 2019 , 41(3) : 185 -192 . DOI: 10.16288/j.yczz.18-244
Recent research in epigenetics suggests that defects in epigenetic regulation of ribosomal DNA (rDNA) transcription may contribute to tumorigenesis. ATRX/DAXX complex is involved in the establishment and maintenance of the silence of the rDNA gene through H3K9me3 modification at histone variant H3.3. The ATRX/DAXX-related genes are frequently mutated in some types of tumors, which may increase rDNA transcription and promote cancer development and progression. In this review, we focus on the mechanism that abnormal transcription of rDNA potentially influences tumorigenesis. We also summarize the epigenetic regulatory mechanism of rDNA transcription, which may provide new theoretical support for drug development based on rDNA transcriptional regulation.
Key words： rDNA; epigenetic regulation; H3.3; ATRX/DAXX; tumorigenesis
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