精神分裂症相关单核苷酸多态性调控microRNA功能研究进展
收稿日期: 2019-05-08
修回日期: 2019-07-07
网络出版日期: 2019-08-05
基金资助
广东省科技计划项目(2019B030316032);广州市科技计划项目(201804010259);国家自然科学基金项目资助(81601175);国家自然科学基金项目资助(81671333)
Schizophrenia-associated single nucleotide polymorphisms affecting microRNA function
Received date: 2019-05-08
Revised date: 2019-07-07
Online published: 2019-08-05
Supported by
Supported by the Guangdong Science and Technology Foundation(2019B030316032);The Guangzhou Science and Technology Foundatio(201804010259);The National Natural Science Foundation of China(81601175);The National Natural Science Foundation of China(81671333)
MicroRNA (miRNAs)是一类长约22nt且对基因表达具有广泛的调控作用的非编码RNA,并在神经元增殖、分化和发育成熟的过程中扮演重要角色。近年来全基因组关联研究(genome-wide association studies, GWAS)发现了众多的精神分裂症相关单核苷酸多态性(single nucleotide polymorphisms, SNPs)位点多位于非编码区,表明miRNA在精神分裂症的发病过程中存在重要作用。本文综述了精神分裂症相关SNP与miRNA可能发生相互作用的4种机制(SNP位于miRNA基因、SNP位于miRNA宿主基因、SNP位于miRNA种子序列和SNP位于miRNA结合位点),为研究miRNA在精神分裂症发生发展中的作用提供参考。
梁文权,侯豫,赵存友 . 精神分裂症相关单核苷酸多态性调控microRNA功能研究进展[J]. 遗传, 2019 , 41(8) : 677 -685 . DOI: 10.16288/j.yczz.19-126
MicroRNAs (miRNAs) compose a class of non-coding transcripts with a mean length of 22 nucleotides, and play critical roles in regulating gene expression in the process of development, proliferation and differentiation of neurons. Recent genome-wide association studies (GWAS) find most of schizophrenia-associated single nucleotide polymorphisms (SNPs) locating in the non-coding regions, providing functional implications of miRNAs in the development of schizophrenia. In this review, we highlight the interplays between GWAS-SNPs and miRNAs in four perspectives: SNP in miRNA gene; miRNA located in the host gene; SNP located in the miRNA’s seed sequence; SNP located in the miRNA’s binding site. We also speculate on the future research on the role of miRNA in the development of schizophrenia.
Key words： GWAS; SNP; miRNA; schizophrenia
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