遗传 >

2019 , Vol. 41 >Issue 11: 994 - 1008

DOI: https://doi.org/10.16288/j.yczz.19-119

综述

MicroRNA调控耳蜗毛细胞发育的分子机制

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  • 浙江大学生命科学学院遗传与再生生物学研究所,浙江省细胞与基因工程重点研究实验室,杭州 310058
饶琳,硕士研究生,专业方向：干细胞分化。E-mail: 21707038@zju.edu.cn

收稿日期: 2019-07-20

  修回日期: 2019-09-26

  网络出版日期: 2019-10-29

基金资助

国家重点基础研究发展规划项目(973计划)资助编号：(2012CB967900)

收起

Molecular mechanism of microRNA in regulating cochlear hair cell development

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  • Key Laboratory for Cell and Gene Engineering of Zhejiang Province, Institute of Genetics and Regenerative Biology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China

Received date: 2019-07-20

  Revised date: 2019-09-26

  Online published: 2019-10-29

Supported by

Supported by the National Program on Key Basic Research Project (973 Program) No(2012CB967900)

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摘要

耳聋是严重影响人类生活质量的全球重大健康问题之一。目前,因耳蜗毛细胞损伤而导致的耳聋疾病尚未有成功的治疗方法。MicroRNA (miRNA)作为一类高度保守的内源性非编码小RNA,在耳蜗以及毛细胞发育过程中发挥着重要作用。本文介绍了miRNA在耳蜗毛细胞产生过程中的时空表达,揭示了其不可或缺的重要作用;同时阐述了miRNA参与调控耳蜗毛细胞发育中相关转录因子的分子机制,为耳聋的毛细胞移植治疗和毛细胞再生研究提供理论参考。

关键词： miRNA; 耳蜗; 听力损失; 毛细胞

本文引用格式

饶琳, 孟飞龙, 房冉, 蔡晨依, 赵小立 . MicroRNA调控耳蜗毛细胞发育的分子机制[J]. 遗传, 2019 , 41(11) : 994 -1008 . DOI: 10.16288/j.yczz.19-119

Abstract

Deafness has become one of the most frequent health problems worldwide, and affects almost every age group. Hair cell damage or absence is the main cause of hearing loss, but there is no successful treatment to heal deafness. MicroRNA (miRNA), as a highly conserved endogenous non-coding small RNA, plays an important role in inner ear cochlea and hair cell development. In this review, we elaborate on the expression and function of miRNAs in cochlear hair cell development, and reveal its indispensable important role. We summarize the molecular mechanism of miRNA in regulating transcription factors involved in cochlear hair cell development, which may provide references and insights for hair cell regeneration in vivo and cellular transplantation therapy of deafness.

Key words： miRNA; cochlea; hearing loss; hair cells

参考文献

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