哺乳动物体细胞核移植表观遗传重编程研究进展
收稿日期: 2019-07-03
修回日期: 2019-10-07
网络出版日期: 2019-11-18
基金资助
国家自然科学基金面上项目资助编号(31772554)
Advances in epigenetic reprogramming of somatic cells nuclear transfer in mammals
Received date: 2019-07-03
Revised date: 2019-10-07
Online published: 2019-11-18
Supported by
Supported by the National Natural Science Foundation of China No(31772554)
体细胞核移植(somatic cell nuclear transfer, SCNT)是唯一能赋予体细胞基因组全能性的生殖工程技术,对动物种质资源保存、畜牧业发展和生物医学研究等具有重大意义。尽管该技术已经取得了许多研究进展,但哺乳动物克隆胚胎的发育效率依然很低,严重限制其在畜牧业和生物医学上的应用。导致克隆胚胎发育效率低的主要原因是体细胞重编程错误或重编程不完全,主要表现为：印记基因Xist表达异常、DNA甲基化异常,组蛋白修饰异常等。本文简要介绍了体细胞核移植技术,系统总结了哺乳动物克隆胚胎发育效率低的主要影响因素,以期为提升体细胞克隆效率相关研究与实践提供理论参考。
杨旭琼, 吴珍芳, 李紫聪 . 哺乳动物体细胞核移植表观遗传重编程研究进展[J]. 遗传, 2019 , 41(12) : 1099 -1109 . DOI: 10.16288/j.yczz.19-193
Somatic cell nuclear transfer (SCNT) is the only reproductive engineering technique that can confer genomic totipotency on somatic cell. SCNT is of great significance for animal germplasm conservation, animal husbandry development, and biomedical research. Although many research advances have been made in this technology, the developmental rate of SCNT mammalian embryos is very low, which seriously limits the application of SCNT in animal husbandry and biomedicine. The primary reason for the low efficiency of cloned embryos is somatic cell reprogramming errors or incomplete reprogramming. These errors or incompleteness present as the abnormal expression of imprinted gene Xist, abnormal DNA methylation, and abnormal histone modification. In this review, we summarize the main factors that influence the low development efficiency of mammalian cloned embryos to provide theoretical reference for the research and practice of improving somatic cell cloning efficiency.
| [1] | Sung LY, Gao S, Shen H, Yu H, Song Y, Smith SL, Chang CC, Inoue K, Kuo L, Lian J, Li A, Tian XC, Tuck DP, Weissman SM, Yang X, Cheng T . Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer. Nat Genet, 2006,38(11):1323-1328. |
| [2] | Matoba S, Zhang Y . Somatic cell nuclear transfer reprogramming: mechanisms and applications. Cell stem Cell, 2018,23(4):471-485. |
| [3] | Rideout WM 3rd, Eggan K, Jaenisch R . Nuclear cloning and epigenetic reprogramming of the genome. Science, 2001,293(5532):1093-1098. |
| [4] | Dinnyés A, Dai Y, Jiang S, Yang X . High developmental rates of vitrified bovine oocytes following parthenogenetic activation, in vitro fertilization, and somatic cell nuclear transfer. Biol Reprod, 2000,63(2):513-518. |
| [5] | Kato Y, Tani T, Tsunoda Y . Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows. J Reprod Fertil, 2000,120(2):231-237. |
| [6] | Lee GS, Hyun SH, Kim HS, Kim DY, Lee SH, Lim JM, Lee ES, Kang SK, Lee BC, Hwang WS . Improvement of a porcine somatic cell nuclear transfer technique by optimizing donor cell and recipient oocyte preparations. Theriogenology, 2003,59(9):1949-1957. |
| [7] | Wilmut I, Schnieke AE, Mcwhir J, Kind AJ, Campbell KHS . Viable offspring derived from fetal and adult mammalian cells. Cloning Stem Cells, 2007,9(1):3-7. |
| [8] | Inoue K, Kohda T, Sugimoto M, Sado T, Ogonuki N, Matoba S, Shiura H, Ikeda R, Mochida K, Fujii T, Sawai K, Otte AP, Tian XC, Yang X, Ishino F, Abe K, Ogura A . Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer. Science, 2010,330(6003):496-499. |
| [9] | Matoba S, Inoue K, Kohda T, Sugimoto M, Mizutani E, Ogonuki N, Nakamura T, Abe K, Nakano T, Ishino F, Ogura A . RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos. Proc Natl Acad Sci USA, 2011,108(51):20621-20626. |
| [10] | Liu WQ, Liu XY, Wang CF, Gao YW, Gao R, Kou XC, Zhao YH, Li JY, Wu Y, Xiu WC, Wang S, Yin JQ, Liu W, Cai T, Wang H, Zhang Y, Gao SR . Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing. Cell Discov, 2016,2:16010. |
| [11] | Matoba S, Liu Y, Lu F, Iwabuchi KA, Shen L, Inoue A, Zhang Y . Embryonic development following somatic cell nuclear transfer impeded by persisting histone methylation. Cell, 2014,159(4):884-895. |
| [12] | Humpherys D, Eggan K, Akutsu H, Friedman A, Hochedlinger K, Yanagimachi R, Lander ES, Golub TR, Jaenisch R . Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei. Proc Natl Acad Sci USA, 2002,99(20):12889-12894. |
| [13] | Xue F, Tian XC, Du F, Kubota C, Taneja M, Dinnyes A, Dai Y, Levine H, Pereira LV, Yang X . Aberrant patterns of X chromosome inactivation in bovine clones. Nat Genet, 2002,31(2):216-220. |
| [14] | Niemann H, Wrenzycki C, Lucas-Hahn A, Brambrink T, Kues WA, Carnwath JW . Gene expression patterns in bovine in vitro-produced and nuclear transfer-derived embryos and their implications for early development. Cloning Stem Cells, 2002,4(1):29-38. |
| [15] | Bourc'his D, Le Bourhis D, Patin D, Niveleau A, Comizzoli P, Renard JP, Viegas-Péquignot E . Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos. Curr Biol, 2001,11(19):1542-1546. |
| [16] | Dean W, Santos F, Stojkovic M, Zakhartchenko V, Walter J, Wolf E, Reik W . Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos. Proc Natl Acad Sci USA, 2001,98(24):13734-13738. |
| [17] | Kang YK, Koo DB, Park JS, Choi YH, Chung AS, Lee KK, Han YM . Aberrant methylation of donor genome in cloned bovine embryos. Nat Genet, 2001,28(2):173-177. |
| [18] | Santos F, Zakhartchenko V, Stojkovic M, Peters A, Jenuwein T, Wolf E, Reik W, Dean W . Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos. Curr Biol, 2003,13(13):1116-1121. |
| [19] | Briggs R, King TJ . Transplantation of living nuclei from blastula cells into enucleated frogs' eggs. Proc Natl Acad Sci USA, 1952,38(5):455-463. |
| [20] | Gurdon JB . The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol, 1962,10:622-640. |
| [21] | Wilmut I, Schnieke AE, Mcwhir J, Kind AJ, Campbell KHS . Viable offspring derived from fetal and adult mammalian cells. Nature, 1997,385(6619):810-813. |
| [22] | Kato Y, Tani T, Sotomaru Y, Kurokawa K, Kato J, Doguchi H, Yasue H, Tsunoda Y . Eight calves cloned from somatic cells of a single adult. Science, 1998,282(5396):2095-2098. |
| [23] | Wakayama T, Perry AC, Zuccotti M, Johnson KR, Yanagimachi R . Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature, 1998,394(6691):369-374. |
| [24] | Baguisi A, Behboodi E, Melican DT, Pollock JS, Destrempes MM, Cammuso C, Williams JL, Nims SD, Porter CA, Midura P, Palacios MJ, Ayres SL, Denniston RS, Hayes ML, Ziomek CA, Meade HM, Godke RA, Gavin WG, Overstr?m EW, Echelard Y . Production of goats by somatic cell nuclear transfer. Nat Biotechnol, 1999,17(5):456-461. |
| [25] | Polejaeva IA, Chen SH, Vaught TD, Page RL, Mullins J, Ball S, Dai Y, Boone J, Walker S, Ayares DL, Colman A, Campbell KH . Cloned pigs produced by nuclear transfer from adult somatic cells. Nature, 2000,407(6800):86-90. |
| [26] | Onishi A, Iwamoto M, Akita T, Mikawa S, Takeda K, Awata T, Hanada H, Perry ACF . Pig cloning by microinjection of fetal fibroblast nuclei. Science, 2000,289(5482):1188-1190. |
| [27] | Chesné P, Adenot PG, Viglietta C, Baratte M, Boulanger L, Renard JP . Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat Biotechnol, 2002,20(4):366-369. |
| [28] | Shin T, Kraemer D, Pryor J, Liu L, Rugila J, Howe L, Buck S, Murphy K, Lyons L, Westhusin M . A cat cloned by nuclear transplantation. Nature, 2002,415(6874):859. |
| [29] | Woods GL, White KL, Vanderwall DK, Li GP, Aston KI, Bunch TD, Meerdo LN, Pate BJ . A mule cloned from fetal cells by nuclear transfer. Science, 2003,301(5636):1063. |
| [30] | Galli C, Lagutina I, Crotti G, Colleoni S, Turini P, Ponderato N, Duchi R, Lazzari G . Pregnancy: a cloned horse born to its dam twin. Nature, 2003,424(6949):635. |
| [31] | Zhou Q, Renard JP, Le Friec G, Brochard V, Beaujean N, Cherifi Y, Fraichard A, Cozzi J . Generation of fertile cloned rats by regulating oocyte activation. Science, 2003,302(5648):1179. |
| [32] | Lee BC, Kim MK, Jang G, Oh HJ, Yuda F, Kim HJ, Hossein MS, Kim JJ, Kang SK, Schatten G, Hwang WS . Dogs cloned from adult somatic cells. Nature, 2005,436(7051):641. |
| [33] | Wani NA, Wernery U, Hassan FA, Wernery R, Skidmore JA . Production of the first cloned camel by somatic cell nuclear transfer. Biol Reprod, 2010,82(2):373-379. |
| [34] | Liu Z, Cai Y, Wang Y, Nie Y, Zhang C, Xu Y, Zhang X, Lu Y, Wang Z, Poo M, Sun Q . Cloning of macaque monkeys by somatic cell nuclear transfer. Cell, 2018, 172(4): 881-887.e7. |
| [35] | Tachibana M, Amato P, Sparman M, Gutierrez NM, Tippner-Hedges R, Ma H, Kang E, Fulati A, Lee HS, Sritanaudomchai H, Masterson K, Larson J, Eaton D, Sadler-Fredd K, Battaglia D, Lee D, Wu D, Jensen J, Patton P, Gokhale S, Stouffer RL, Wolf D, Mitalipov S . Human embryonic stem cells derived by somatic cell nuclear transfer. Cell, 2013,153(6):1228-1238. |
| [36] | Chung YG, Matoba S, Liu Y, Eum JH, Lu F, Jiang W, Lee JE, Sepilian V, Cha KY, Lee DR, Zhang Y . Histone demethylase expression enhances human somatic cell nuclear transfer efficiency and promotes derivation of pluripotent stem cells. Cell Stem Cell, 2015,17(6):758-766. |
| [37] | Yamada M, Johannesson B, Sagi I, Burnett LC, Kort DH, Prosser RW, Paull D, Nestor MW, Freeby M, Greenberg E, Goland RS, Leibel RL, Solomon SL, Benvenisty N, Sauer MV, Egli D . Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells. Nature, 2014,510(7506):533-536. |
| [38] | Wakayama T, Tabar V, Rodriguez I, Perry AC, Studer L, Mombaerts P . Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science, 2001,292(5517):740-743. |
| [39] | Rideout WM 3rd, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R . Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell, 2002,109(1):17-27. |
| [40] | Byrne JA, Pedersen DA, Clepper LL, Nelson M, Sanger WG, Gokhale S, Wolf DP, Mitalipov SM . Producing primate embryonic stem cells by somatic cell nuclear transfer. Nature, 2007,450(7169):497-502. |
| [41] | Chung YG, Eum JH, Lee JE, Shim SH, Sepilian V, Hong SW, Lee Y, Treff NR, Choi YH, Kimbrel EA, Dittman RE, Lanza R, Lee DR . Human somatic cell nuclear transfer using adult cells. Cell Stem Cell, 2014,14(6):777-780. |
| [42] | Zhang J, Liu H, Luo S, Lu Z, Chávez-Badiola A, Liu Z, Yang M, Merhi Z, Silber SJ, Munné S, Konstantinidis M, Wells D, Tang JJ, Huang T . Live birth derived from oocyte spindle transfer to prevent mitochondrial disease. Reprod Biomed Online, 2017,34(4):361-368. |
| [43] | Lai L, Prather RS . Production of cloned pigs by using somatic cells as donors. Cloning Stem Cells, 2003,5(4):233-241. |
| [44] | Liu Y, Li J, L?vendahl P, Schmidt M, Larsen K, Callesen H . In vitro manipulation techniques of porcine embryos: a meta-analysis related to transfers, pregnancies and piglets. Reprod Fertil Dev, 2015,27(3):429-439. |
| [45] | Ogura A, Inoue K, Wakayama T . Recent advancements in cloning by somatic cell nuclear transfer. Philos Trans R Soc Lond B Biol Sci, 2013,368(1609):20110329. |
| [46] | Ao Z, Liu DW, Cai GY, Wu ZF, Li ZC . Placental developmental defects in cloned mammalian animals. Hereditas(Beijing), 2016,38(5):402-410. |
| [46] | 敖政, 刘德武, 蔡更元, 吴珍芳, 李紫聪 . 克隆哺乳动物的胎盘发育缺陷. 遗传, 2016,38(5):402-410. |
| [47] | Loi P, Iuso D, Czernik M, Ogura A . A New, Dynamic era for somatic cell nuclear transfer? Trends Biotechnol, 2016,34(10):791-797. |
| [48] | Ao Z, Liu D, Zhao C, Yue Z, Shi J, Zhou R, Cai G, Zheng E, Li Z, Wu Z . Birth weight, umbilical and placental traits in relation to neonatal loss in cloned pigs. Placenta, 2017,57:94-101. |
| [49] | Oback B . Climbing mount efficiency--small steps, not giant leaps towards higher cloning success in farm animals. Reprod Domest Anim, 2008,43(s2):407-416. |
| [50] | Yang X, Smith SL, Tian XC, Lewin HA, Renard JP, Wakayama T . Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning. Nat Genet, 2007,39(3):295-302. |
| [51] | Graves JAM . Sex chromosome specialization and degeneration in mammals. Cell, 2006,124(5):901-914. |
| [52] | Sahakyan A, Yang Y, Plath K . The role of Xist in X-chromosome dosage compensation. Trends Cell Biol, 2018,28(12):999-1013. |
| [53] | Furlan G, Rougeulle C . Function and evolution of the long noncoding RNA circuitry orchestrating X-chromosome inactivation in mammals. Wiley Interdiscip Rev RNA, 2016,7(5):702-722. |
| [54] | Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I . Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature, 2010,467(7318):977-981. |
| [55] | Payer B . Developmental regulation of X-chromosome inactivation. Semin Cell Dev Biol, 2016,56:88-99. |
| [56] | Moreira De Mello JC, De Araújo ES, Stabellini R, Fraga AM, De Souza JES, Sumita DR, Camargo AA, Pereira LV . Random X inactivation and extensive mosaicism in human placenta revealed by analysis of allele-specific gene expression along the X chromosome. PLoS One, 2010,5(6):e10947. |
| [57] | Zeng F, Huang ZH, Yuan YJ, Shi JS, Cai GY, Liu DW, Wu ZF, Li ZC . Effects of RNAi-mediated knockdown of Xist on the developmental efficiency of cloned male porcine embryos. J Reprod Dev, 2016,62(6):591-597. |
| [58] | Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y . Role of histone H3 lysine 27 methylation in polycomb-group silencing. Science, 2002,298(5595):1039-1043. |
| [59] | Nora EP, Heard E . Chromatin structure and nuclear organization dynamics during X-chromosome inactivation. Cold Spring Harb Symp Quant Biol, 2010,75:333-344. |
| [60] | Fukuda A, Cao F, Morita S, Yamada K, Jincho Y, Tane S, Sotomaru Y, Kono T . Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts. PloS One, 2010,5(6):e11274. |
| [61] | Yuan L, Wang AF, Yao CG, Huang YY, Duan FF, Lv QY, Wang DX, Ouyang HS, Li ZJ, Lai LX . Aberrant expression of Xist in aborted porcine fetuses derived from somatic cell nuclear transfer embryos. Int J Mol Sci, 2014,15(12):21631-21643. |
| [62] | Chen XY, Zhu ZW, Yu FX, Huang J, Jia RX, Pan JZ . Effect of shRNA-mediated Xist knockdown on the quality of porcine parthenogenetic embryos. Dev Dyn, 2019,248(1):140-148. |
| [63] | Yang Y, Wu D, Liu D, Shi J, Zhou R, He X, Quan J, Cai G, Zheng E, Wu Z, Li Z . Mutation of the XIST gene upregulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos. Mol Reprod Dev, 2017,84(6):525-534. |
| [64] | Ruan D, Peng J, Wang X, Ouyang Z, Zou Q, Yang Y, Chen F, Ge W, Wu H, Liu Z, Zhao Y, Zhao B, Zhang Q, Lai C, Fan N, Zhou Z, Liu Q, Li N, Jin Q, Shi H, Xie J, Song H, Yang X, Chen J, Wang K, Li X, Lai L . XIST derepression in active X chromosome hinders pig somatic cell nuclear transfer. Stem Cell Reports, 2018,10(2):494-508. |
| [65] | Sulewska A, Niklinska W, Kozlowski M, Minarowski L, Naumnik W, Niklinski J, Dabrowska K, Chyczewski L . DNA methylation in states of cell physiology and pathology. Folia Histochem Cytobiol, 2007,45(3):149-158. |
| [66] | Guo L, Li H, Han ZM . Effect of DNA methylation and histone modification during the de-velopment of cloned animals. Hereditas(Beijing), 2010,32(8):762-768. |
| [66] | 郭磊, 李慧, 韩之明 . DNA甲基化和组蛋白修饰在克隆动物发育过程中的作用. 遗传, 2010,32(8):762-768. |
| [67] | Song HW, An TZ, Piao SH, Wang CS . Mammalian DNA methylation and its roles during the induced re-programming of somatic cells. Hereditas(Beijing), 2014,36(5):431-438. |
| [67] | 宋红卫, 安铁洙, 朴善花, 王春生 . 哺乳动物DNA甲基化及其在体细胞诱导重编程中的作用. 遗传, 2014,36(5):431-438. |
| [68] | Deng DJ . DNA methylation and demethylation: current status and future per-spective. Hereditas(Beijing), 2014,36(5):403-410. |
| [68] | 邓大君 . DNA甲基化和去甲基化的研究现状及思考. 遗传, 2014,36(5):403-410. |
| [69] | Wu X, Zhang Y . TET-mediated active DNA demethylation: mechanism, function and beyond. Nat Rev Genet, 2017,18(9):517-534. |
| [70] | Mayer W, Niveleau A, Walter J, Fundele R, Haaf T . Demethylation of the zygotic paternal genome. Nature, 2000,403(6769):501-502. |
| [71] | Simonsson S, Gurdon J . DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol, 2004,6(10):984-990. |
| [72] | Zhang Y, Charlton J, Karnik R, Beerman I, Smith ZD, Gu H, Boyle P, Mi X, Clement K, Pop R, Gnirke A, Rossi DJ, Meissner A. Targets and genomic constraints of ectopic Dnmt3b expression. eLife, 2018, 7: pii: e40757. |
| [73] | Inoue A, Zhang Y . Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science, 2011,334(6053):194. |
| [74] | Matoba S, Wang H, Jiang L, Lu F, Iwabuchi KA, Wu X, Inoue K, Yang L, Press W, Lee JT, Ogura A, Shen L, Zhang Y. Loss of H3K27me3 imprinting in somatic cell nuclear transfer embryos disrupts post-implantation development. Cell Stem Cell, 2018, 23(3): 343-354.e345. |
| [75] | Gao R, Wang C, Gao Y, Xiu W, Chen J, Kou X, Zhao Y, Liao Y, Bai D, Qiao Z, Yang L, Wang M, Zang R, Liu X, Jia Y, Li Y, Zhang Y, Yin J, Wang H, Wan X, Liu W, Zhang Y, Gao S . Inhibition of aberrant DNA re-methylation improves post-implantation development of somatic cell nuclear transfer embryos. Cell Stem Cell, 2018, 23(3): 426-435.e425. |
| [76] | Johnstone RW . Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat Rev Drug Discov, 2002,1(4):287-299. |
| [77] | Ji HL, Lu SS, Pan DK . Epigenetic reprogramming by somatic cell nuclear transfer: questions and potential solutions. Hereditas(Beijing), 2014,36(12):1211-1218. |
| [77] | 纪慧丽, 卢晟盛, 潘登科 . 体细胞核移植后表观遗传重编程的异常及其修复. 遗传, 2014,36(12):1211-1218. |
| [78] | Kishigami S, Mizutani E, Ohta H, Hikichi T, Thuan NV, Wakayama S, Bui HT, Wakayama T . Significant improvement of mouse cloning technique by treatment with trichostatin a after somatic nuclear transfer. Biochem Biophys Res Commun, 2006,340(1):183-189. |
| [79] | Rybouchkin A, Kato Y, Tsunoda Y . Role of histone acetylation in reprogramming of somatic nuclei following nuclear transfer. Biol Reprod, 2006,74(6):1083-1089. |
| [80] | Inoue K, Oikawa M, Kamimura S, Ogonuki N, Nakamura T, Nakano T, Abe K, Ogura A . Trichostatin a specifically improves the aberrant expression of transcription factor genes in embryos produced by somatic cell nuclear transfer. Sci Rep, 2015,5:10127. |
| [81] | Bohrer RC, Duggavathi R, Bordignon V . Inhibition of histone deacetylases enhances DNA damage repair in SCNT embryos. Cell Cycle, 2014,13(13):2138-2148. |
| [82] | Jin JX, Kang JD, Li S, Jin L, Zhu HY, Guo Q, Gao QS, Yan CG, Yin XJ . PXD101 significantly improves nuclear reprogramming and the in vitro developmental competence of porcine SCNT embryos. Biochem Biophys Res Commun, 2015,456(1):156-161. |
| [83] | Akagi S, Matsukawa K, Mizutani E, Fukunari K, Kaneda M, Watanabe S, Takahashi S . Treatment with a histone deacetylase inhibitor after nuclear transfer improves the preimplantation development of cloned bovine embryos. J Reprod Dev, 2011,57(1):120-126. |
| [84] | Li X, Ao X, Bai L, Li D, Liu X, Wei Z, Bou S, Li G . VPA selectively regulates pluripotency gene expression on donor cell and improve SCNT embryo development. In Vitro Cell Dev Biol Anim, 2018,54(7):496-504. |
| [85] | Song BS, Yoon SB, Sim BW, Kim YH, Cha JJ, Choi SA, Jeong KJ, Kim JS, Huh JW, Lee SR, Kim SH, Kim SU, Chang KT . Valproic acid enhances early development of bovine somatic cell nuclear transfer embryos by alleviating endoplasmic reticulum stress. Reprod Fertil Dev, 2014,26(3):432-440. |
| [86] | Zhao J, Hao Y, Ross JW, Spate LD, Walters EM, Samuel MS, Rieke A, Murphy CN, Prather RS . Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. Cell Reprogram, 2010,12(1):75-83. |
| [87] | Martinez-Diaz MA, Che L, Albornoz M, Seneda MM, Collis D, Coutinho AR, El-Beirouthi N, Laurin D, Zhao X, Bordignon V . Pre-and postimplantation development of swine-cloned embryos derived from fibroblasts and bone marrow cells after inhibition of histone deacetylases. Cell Reprogram, 2010,12(1):85-94. |
| [88] | Wang C, Liu X, Gao Y, Yang L, Li C, Liu W, Chen C, Kou X, Zhao Y, Chen J, Wang Y, Le R, Wang H, Duan T, Zhang Y, Gao S . Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development. Nat Cell Biol, 2018,20(5):620-631. |
| [89] | Djekidel MN, Inoue A, Matoba S, Suzuki T, Zhang CX, Lu FL, Jiang L, Zhang Y . Reprogramming of chromatin accessibility in somatic cell nuclear transfer is DNA replication independent. Cell Rep, 2018,23(7):1939-1947. |
| [90] | Liu X, Wang Y, Gao Y, Su J, Zhang J, Xing X, Zhou C, Yao K, An Q, Zhang Y. H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming. Development, 2018, 145(4), pii: dev158261. |
| [91] | Hang XW, Cheng XR, Wang N, Zhang YW, Liao C, Jin LH, Lei L . Histone variant H3.3 and its functions in reprogramming. Hereditas(Beijing), 2018,40(3):186-196. |
| [91] | 黄星卫, 程香荣, 王楠, 张雨薇, 廖辰, 金连弘, 雷蕾 . 组蛋白H3变体H3.3及其在细胞重编程中的作用. 遗传, 2018,40(3):186-196. |
| [92] | Inoue A, Jiang L, Lu F, Suzuki T, Zhang Y . Maternal H3K27me3 controls DNA methylation-independent imprinting. Nature, 2017,547(7664):419-424. |
| [93] | Inoue A, Jiang L, Lu F, Zhang Y . Genomic imprinting of Xist by maternal H3K27me3. Genes Dev, 2017,31(19):1927-1932. |
| [94] | Keefer CL . Lessons learned from nuclear transfer (cloning). Theriogenology, 2008,69(1):48-54. |
| [95] | Bai GY, Song SH, Zhang YW, Huang X, Huang XW, Sun RZ, Lei L . Kdm6a overexpression improves the development of cloned mouse embryos. Zygote, 2018,26(1):24-32. |
| [96] | K L, Chen YJ, Gao SR. Historical review of reprogramming and pluripotent stem cell research in China. Hereditas(Beijing), 2018,40(10):825-840. |
| [96] | 康岚, 陈嘉瑜, 高绍荣 . 中国细胞重编程和多能干细胞研究进展. 遗传, 2018,40(10):825-840. |
| [97] | Lu F, Liu Y, Inoue A, Suzuki T, Zhao K, Zhang Y . Establishing chromatin regulatory landscape during mouse preimplantation development. Cell, 2016,165(6):1375-1388. |
| [98] | Ke Y, Xu Y, Chen X, Feng S, Liu Z, Sun Y, Yao X, Li F, Zhu W, Gao L, Chen H, Du Z, Xie W, Xu X, Huang X, Liu J. . 3D chromatin structures of mature gametes and structural reprogramming during mammalian embryogenesis. Cell, 2017, 170(2): 367-381.e320. |
| [99] | Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, Rathert P, Jude J, Ferrari F, Blanco A, Fellner M, Wenzel D, Zinner M, Vidal SE, Bell O, Stadtfeld M, Chang HY, Almouzni G, Lowe SW, Rinn J, Wernig M, Aravin A, Shi Y, Park PJ, Penninger JM, Zuber J, Hochedlinger K . The histone chaperone CAF-1 safeguards somatic cell identity. Nature, 2015,528(7581):218-224. |
| [100] | Soufi A, Donahue G, Zaret KS . Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell, 2012,151(5):994-1004. |
| [101] | Sridharan R, Gonzales-Cope M, Chronis C, Bonora G, Mckee R, Huang CY, Patel S, Lopez D, Mishra N, Pellegrini M, Carey M, Garcia BA, Plath K . Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1γ in reprogramming to pluripotency. Nat Cell Biol, 2013,15(7):872-882. |
| [102] | Okae H, Matoba S, Nagashima T, Mizutani E, Inoue K, Ogonuki N, Chiba H, Funayama R, Tanaka S, Yaegashi N, Nakayama K, Sasaki H, Ogura A, Arima T . RNA sequencing-based identification of aberrant imprinting in cloned mice. Hum Mol Genet, 2014,23(4):992-1001. |
| [103] | Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES . Optimal-transport asnalysis of single-cell gene expression identifies developmental trajectories in reprogramming. Cell, 2019, 176(4): 928-943.e922. |
| [104] | Fan ZQ, Yang M, Regouski M, Polejaeva IA . Gene knockouts in goats using CRISPR/Cas9 system and somatic cell nuclear transfer. Methods Mol Biol, 2019,1874:373-390. |
| [105] | Sander JD, Joung JK . CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol, 2014,32(4):347-355. |
/
| 〈 |
|
〉 |
www.chinagene.cn
备案号：京ICP备09063187号-4
总访问:,今日访问:,当前在线:
