环状RNA翻译能力研究进展
收稿日期: 2020-01-07
修回日期: 2020-03-24
网络出版日期: 2020-04-01
基金资助
国家自然科学基金项目编号(31772578);国家自然科学基金项目编号(31672402);四川省科技支撑计划项目资助编号(2016NYZ0045)
Progress on translation ability of circular RNA
Received date: 2020-01-07
Revised date: 2020-03-24
Online published: 2020-04-01
Supported by
Supported by the National Natural Science Foundation of China Nos(31772578);Supported by the National Natural Science Foundation of China Nos(31672402);the Science and Technology Program of Sichuan Province No(2016NYZ0045)
郑帅龙, 李利, 张红平 . 环状RNA翻译能力研究进展[J]. 遗传, 2020 , 42(5) : 423 -434 . DOI: 10.16288/j.yczz.19-354
With the rapid development of high-throughput sequencing technology and translatome studies, the translational ability of circular RNA (circRNA) has gradually attracted much attention. Previous studies have shown that circRNA itself can be translated into proteins, whose function is closely related to the occurrence and development of human diseases. And it is expected to become an ideal substitute for mRNA, which can be widely used in protein engineering in the future. In this review, we systematically summarize the sources, biogenesis and features of circRNA, the driving models of circRNA translation, identification and functional verification of circRNA translation. We also sum up the latest research progress of circRNA translation in human diseases and its application in protein engineering, and make prospective anticipations for future research directions, which may offer more theoretical references for related researches in this field.
Key words： circular RNA; protein translation; identification methods
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