泛素化途径在奶牛乳脂生成过程中的调控作用
收稿日期: 2020-02-10
修回日期: 2020-04-15
网络出版日期: 2020-05-07
基金资助
国家自然科学基金项目资助编号(31902152);国家自然科学基金项目资助编号(31872327)
The regulation of ubiquitination in milk fat synthesis in bovine
Received date: 2020-02-10
Revised date: 2020-04-15
Online published: 2020-05-07
Supported by
Supported by the National Natural Science Foundation of China Nos(31902152);Supported by the National Natural Science Foundation of China Nos(31872327)
刘莉莉, 郭爱伟, 李青青, 吴培福, 杨亚晋, 陈粉粉, 李素华, 郭盘江, 张勤 . 泛素化途径在奶牛乳脂生成过程中的调控作用[J]. 遗传, 2020 , 42(6) : 548 -555 . DOI: 10.16288/j.yczz.20-037
Ubiquitination signaling is the main pathway of protein degradation in eukaryotic cells. Ubiquitin-proteasome system degrades the ubiquitinated cytoplasmic proteins and lysosome pathway mainly degrades the ubiquitinated membrane proteins. Previous studies have shown that ubiquitination signaling plays a critical role in fatty acids synthesis. In the process of fatty acids import, disruption of ubiquitination could prevent the degradation of fatty acid transport proteins, thereby promoting fatty acids import and milk fat synthesis in bovine primary mammary epithelial cells. In this review, we summarize the signal transduction and regulation mechanism of ubiquitination signaling in milk fat synthesis, which may provide references and new ideas for future research on milk fat traits in dairy cows.
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