miRNA与肾脏发育
收稿日期: 2020-07-16
修回日期: 2020-09-30
网络出版日期: 2020-10-15
基金资助
国家自然科学基金项目编号(81872943);国家自然科学基金项目编号(81220108026);国家自然科学基金项目编号(81430089);国家自然科学基金项目编号(81001466);湖北省卫计委项目编号(WJ2017M002);湖北省自然科学基金项目资助编号(2017CFB649)
The role of miRNA in kidney development
Received date: 2020-07-16
Revised date: 2020-09-30
Online published: 2020-10-15
Supported by
Supported by the National Natural Science Foundation of China Nos(81872943);Supported by the National Natural Science Foundation of China Nos(81220108026);Supported by the National Natural Science Foundation of China Nos(81430089);Supported by the National Natural Science Foundation of China Nos(81001466);Hubei Province health and Family Planning Scientific Research Project No(WJ2017M002);the Natural Science Foundation of Hubei Province No(2017CFB649)
赵晓琪, 敖英, 陈海云, 汪晖 . miRNA与肾脏发育[J]. 遗传, 2020 , 42(11) : 1062 -1072 . DOI: 10.16288/j.yczz.20-112
MicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are closely related to kidney development and diseases, suggesting that miRNAs are important regulators in kidney physiology and pathology. This review will focus on the research progress of miRNA in kidney development, and discuss the role of miRNAs in the occurrence and development of renal dysplasia, which will provide a reference for the diagnosis and research of diseases related to kidney development.
Key words： microRNAs; kidney development; kidney dysplasia; mechanism; diagnosis
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