Rab蛋白家族在神经类疾病中的作用
收稿日期: 2020-11-17
修回日期: 2021-01-06
网络出版日期: 2021-01-12
基金资助
国家自然科学基金项目资助编号(81701260)
The roles of Rab protein family in neurological diseases
Received date: 2020-11-17
Revised date: 2021-01-06
Online published: 2021-01-12
Supported by
Supported by the National Natural Science Foundation of China No(81701260)
吴安平, 庆宏, 全贞贞 . Rab蛋白家族在神经类疾病中的作用[J]. 遗传, 2021 , 43(1) : 16 -29 . DOI: 10.16288/j.yczz.20-318
The intracellular membrane trafficking is a complicated pathway network. Rab GTPases are key regulators of membrane trafficking that are generally considered as specific markers and indicators of various organelles and membrane trafficking in endocytic and secretory pathways. Dysfunction in axonal and endosomal transport related to Rab proteins is one of the most important causes of neurodegenerative diseases. In this review, we mainly introduce how the Rab proteins change in different neurodegenerative diseases and their regulatory roles in the pathological mechanisms of related diseases. We also discuss the relationships between mitochondrial and glial cell dysfunctions and Rab proteins. Further exploration of the regulatory roles of Rab proteins will shed lights on revealing the pathogenic mechanisms of neurological diseases and providing potential targets for the early diagnosis and treatment of neurological diseases.
Key words： Rab proteins; neurological diseases; membrane trafficking; mitochondria; astrocytes
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