精子变形过程中组蛋白-鱼精蛋白替换调控机制
收稿日期: 2021-06-10
修回日期: 2021-10-27
网络出版日期: 2021-11-10
基金资助
国家自然科学基金项目,江苏省高校自然科学研究重大项目和扬州大学研究生科研创新计划项目资助(82071696);国家自然科学基金项目,江苏省高校自然科学研究重大项目和扬州大学研究生科研创新计划项目资助(82101674);江苏省高校自然科学研究重大项目编号(20KJA310002);扬州大学研究生科研创新计划项目(编号：XKYCX20_35)资助(XKYCX20_35)
Regulation of histone-to-protamine transition during spermiogenesis
Received date: 2021-06-10
Revised date: 2021-10-27
Online published: 2021-11-10
Supported by
Supported by the National Natural Science Foundation of China(82071696);Supported by the National Natural Science Foundation of China(82101674);the Key Scientific Project for Jiangsu Provincial Universities No(20KJA310002);the Postgraduate Scientific Research Innovation Program of Yangzhou University No(XKYCX20_35)
精子形成是精子发生的最后阶段,圆形精子细胞经历了一系列的形态变化和染色质凝聚,形成了具有物种特异性的成熟精子。组蛋白-鱼精蛋白替换是精子形成过程中的重要事件。在组蛋白-鱼精蛋白替换过程中,组蛋白首先被睾丸特异性的组蛋白变体所替代,随后过渡蛋白整合到细胞核中,最后过渡蛋白被鱼精蛋白取代。组蛋白-鱼精蛋白替换缺陷可能导致无精子症、少精子症或畸精症,从而导致男性不育。本文系统总结了组蛋白-鱼精蛋白替换过程中的调控机制研究进展,以期为男性不育症的诊断和治疗提供理论基础。
关键词： 精子发生; 组蛋白-鱼精蛋白替换; 翻译后修饰
袁露, 葛婷婷, 牛长敏, 徐文华, 郑英 . 精子变形过程中组蛋白-鱼精蛋白替换调控机制[J]. 遗传, 2021 , 43(12) : 1121 -1131 . DOI: 10.16288/j.yczz.21-205
Spermiogenesis is the final stage of spermatogenesis, in which round spermatids differentiate into mature sperms through a complex process including morphological changes and chromatin condensation. Histone-to-protamine transition during spermiogenesis is a critical part of this biological process. Histones are initially replaced by testis-specific histone variants, then transition proteins integrate into the nucleus, and are in turn replaced by protamine. Impaired histone-to-protamine transition may cause azoospermia, oligospermia or teratospermia, which lead to male infertility. In this review, we summarize the research progress of regulatory mechanisms of the histone-to-protamine transition, thereby providing the theoretical basis for the diagnosis and treatment of male infertility.
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