炎性衰老在血液系统疾病中的研究进展
收稿日期: 2021-10-05
修回日期: 2021-11-10
网络出版日期: 2021-11-18
基金资助
国家自然科学基金项目资助(81773397);国家自然科学基金项目资助(82073520)
Progress on inflamm-aging in hematologic diseases
Received date: 2021-10-05
Revised date: 2021-11-10
Online published: 2021-11-18
Supported by
Supported by the National Natural Science Foundation of China(81773397);Supported by the National Natural Science Foundation of China(82073520)
刘紫妍, 高艾 . 炎性衰老在血液系统疾病中的研究进展[J]. 遗传, 2021 , 43(12) : 1132 -1141 . DOI: 10.16288/j.yczz.21-261
With the increasing human life expectancy, the aging of the global population is intensifying, and the incidence of senile diseases is rising accordingly. Inflamm-aging refers to the phenomenon that the body's pro-inflammatory state increases with age. Studies have shown that inflamm-aging is related to cardiovascular and cerebrovascular diseases, neurodegenerative diseases, and osteoarthropathy, but its mechanism is still unclear, especially in blood system diseases. How systemic inflammation causes hematopoietic disorders through aging and then participates in the occurrence of hematological system diseases remains unclarified. This article reviews the pathogenesis of inflamm-aging, and the relationship between inflamm-aging and hematological diseases. It aims to reveal the possible mechanism of inflamm-aging in hematological diseases and provides a reference for the prevention and treatment of hematological diseases.
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