通过时间基因表达谱分析探究异烟肼引起肝损伤的机制
收稿日期: 2022-03-10
修回日期: 2022-04-26
网络出版日期: 2022-05-11
基金资助
国家自然科学基金项目资助编号(81773818);国家自然科学基金项目资助编号(82003856)
Analysis of time-series gene expression data to explore mechanisms of isoniazid-induced liver toxicity
Received date: 2022-03-10
Revised date: 2022-04-26
Online published: 2022-05-11
Supported by
Supported by the National Nature Science Foundation of China Nos(81773818);Supported by the National Nature Science Foundation of China Nos(82003856)
田子钊, 周晨希, 周伟, 李沫, 褚云鹏, 怀聪, 秦胜营 . 通过时间基因表达谱分析探究异烟肼引起肝损伤的机制[J]. 遗传, 2022 , 44(6) : 501 -509 . DOI: 10.16288/j.yczz.22-069
Isoniazid (INH) is a first-line anti-tuberculosis drug which can cause idiosyncratic liver injury, while the underlying mechanisms need to be further elucidated. In this study, we explored the time series gene expression profiling of a hepatocyte cell line under isoniazid treatment. Through cluster analysis and enrichment analysis of differentially expressed genes, we revealed a total of 6 gene clusters and a series of pathways related to hepatotoxicity, and 13 key candidate genes were identified according to the protein-protein interaction (PPI) network analysis and maSigPro analysis. These findings lay a foundation for understanding the mechanisms of isoniazid -induced liver toxicity and provide new target genes for the monitoring and treatment of INH-induced hepatotoxicity in the future.
Key words： isoniazid; hepatocytes; liver toxicity; time series analysis
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