血液发生相关microRNAs研究进展
收稿日期: 2022-06-15
修回日期: 2022-08-03
网络出版日期: 2022-08-26
基金资助
国家重点研发计划项目(编号)(2018YFD0900601);国家重点研发计划项目(编号)(2018YFC0310600);国家自然科学基金面上项目(编号)(31772826);上海市教委重点科技创新项目(编号)资助(2017-01-07-00-10-E00060)
Research progress of microRNAs involved in hematopoiesis
Received date: 2022-06-15
Revised date: 2022-08-03
Online published: 2022-08-26
Supported by
Supported by the National Key Research and Development Program of China Nos(2018YFD0900601);Supported by the National Key Research and Development Program of China Nos(2018YFC0310600);the National Natural Science Foundation of China No(31772826);the Major Science Innovation Grant from the Shanghai Education Committee No(2017-01-07-00-10-E00060)
血液发生对生命体有着十分重要的意义。脊椎动物的血液发生主要表现为造血干细胞的自我更新和分化、造血祖细胞的增殖分化以及血细胞的成熟。血液发生过程的调控涉及多种转录因子、膜受体、造血生长因子和microRNAs等,它们之间相互作用形成多种信号通路及信号通路网。microRNAs是一类非编码RNA,广泛分布于真核生物细胞中,在机体的造血过程中发挥着重要作用。microRNAs的表达受造血相关信号通路中转录因子的调控,而microRNAs的表达能抑制或降低参与造血相关信号通路的转录因子以及更多造血相关调控因子的表达,从而影响血细胞发生相关的信号通路,进而调控造血过程。本文主要介绍了脊椎动物造血过程和血细胞发生相关信号通路,并围绕microRNAs与造血相关转录因子及信号通路之间的作用关系,总结了microRNAs调控血液发生的相关研究进展。
孙凤宇, 许强华 . 血液发生相关microRNAs研究进展[J]. 遗传, 2022 , 44(9) : 756 -771 . DOI: 10.16288/j.yczz.22-198
Hematopoiesis plays an important role(s) in maintenance and physiology of life. Hematopoiesis in vertebrates mainly includes self-renewal of the hematopoietic stem cells, proliferation and differentiation of the hematopoietic progenitor cells, and maturation of the blood cells. The regulation of hematogenesis involves a variety of transcription factors, membrane receptors, hematopoietic growth factors, and microRNAs, which interact with each other and form a variety of signaling pathways and signal networks. MicroRNAs are a class of non-coding RNAs widely distributed in eukaryotic cells and play important roles in the hematopoietic process. The expression of microRNAs is regulated by transcription factors involved in hematopoietic signaling pathways. In turn, their expression can inhibit or down-regulate those of transcription factors involved in hematopoietic related signaling pathways and other related regulatory factors, thereby affecting the signaling pathways related to hematopoiesis and ultimately the hematopoietic process. In this review, we introduce the hematopoiesis processes and related signal pathways in vertebrates, focusing on the relationships between microRNAs and hematopoietic transcription factors and signal pathways, and summarizing the recent research progress of microRNAs in hematopoiesis.
Key words： hematopoiesis; transcription factor; signal pathway; microRNAs
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