肝脏分泌因子与代谢性疾病
收稿日期: 2022-06-27
修回日期: 2022-09-06
网络出版日期: 2022-09-20
基金资助
国家自然科学基金(31800992);江苏省自然科学基金(BK20180554)
Interaction between hepatokines and metabolic diseases
Received date: 2022-06-27
Revised date: 2022-09-06
Online published: 2022-09-20
Supported by
the Natural Science Foundation of China(31800992);the Natural Science Foundation of JiangSu(BK20180554)
代谢性疾病泛指代谢功能发生问题所引起的疾病,其主要症状包括中心性肥胖、胰岛素抵抗、血脂血糖异常、血压升高等。肝脏作为人体内一个重要的代谢器官,在调节全身葡萄糖和脂质代谢等许多生理过程中起关键作用。近年来的大量研究表明,肝脏可以合成和分泌多种生物信号分子,如FGF21、Fetuin-A以及ANGPTL8等,以自分泌/旁分泌的方式调节机体的代谢过程。干预相关肝脏分泌因子的表达可有助于预防、诊断和治疗代谢性疾病。然而,目前肝脏分泌因子与代谢稳态之间的互作机制仍不明确。本文对不同肝脏分泌因子与代谢性疾病的关系展开论述,以期为治疗代谢性疾病提供新的策略和参考。
梁佳琦, 刘畅, 张雯翔, 陈思禹 . 肝脏分泌因子与代谢性疾病[J]. 遗传, 2022 , 44(10) : 853 -866 . DOI: 10.16288/j.yczz.22-218
Metabolic diseases are broadly defined as diseases caused by problems in metabolic function, including central obesity, insulin resistance, lipid glucose abnormalities, and elevated blood pressure. As an important metabolic organ, the liver plays a key role in regulating many physiological processes such as systemic glucose and lipid metabolism. Numerous studies in recent years have shown that the liver can synthesize and secrete a variety of hepatokines, including FGF21, Fetuin-A and ANGPTL8, which regulate the metabolism in an autocrine/paracrine manner. Intervention of hepatokines expression may contribute to the prevention, diagnosis and treatment of metabolic diseases. However, further studies are needed to be investigated as the mechanism of hepatokines and metabolic homeostasis is still elusive. In this review, we summarize the relationships between hepatokines and metabolic diseases in order to provide new strategies for the treatment of metabolic diseases.
Key words： hepatokines; metabolic diseases; diagnosis and therapy
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