FSCN1在乳腺癌发生发展中的作用及其调控机制
收稿日期: 2022-11-01
修回日期: 2022-12-27
网络出版日期: 2022-12-28
基金资助
国家自然科学基金项目(82273460);国家自然科学基金项目(32260167);云南省应用基础研究基金(202101AV070002);云南省应用基础研究基金(2019FY003030);云南省科技计划重大专项(202102AA310055);云南大学研究生科研创新项目(ZC-22223017);云南大学研究生科研创新项目(KC-22222424);国家卫生健康委毒品依赖和戒治重点实验室开放课题(2020DAMOP-005)
The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression
Received date: 2022-11-01
Revised date: 2022-12-27
Online published: 2022-12-28
Supported by
the National Natural Science Foundation of China(82273460);the National Natural Science Foundation of China(32260167);the Applied Basic Research Foundation of Yunnan Province(202101AV070002);the Applied Basic Research Foundation of Yunnan Province(2019FY003030);the Major Science and Technique Programs in Yunnan Province(202102AA310055);the Graduate Scientific Research Innovation Project of Yunnan University(ZC-22223017);the Graduate Scientific Research Innovation Project of Yunnan University(KC-22222424);the NHC Key Laboratory of Drug Addiction Medicine(2020DAMPO-005)
FSCN1是一种肌动蛋白结合蛋白，能够将肌动蛋白丝集成一束。FSCN1在几乎所有的转移性肿瘤中高表达，并与大部分肿瘤的不良预后密切相关。FSCN1在基底样和三阴性乳腺癌中高度表达。近年来关于FSCN1的报道愈发频繁，随着深入研究发现，FSCN1除了促进癌细胞的迁移、侵袭和转移定植，维持癌细胞自我更新和增强耐药性，还具有调控癌细胞的糖脂代谢及线粒体重塑等功能。本文从FSCN1的结构和调节形式，促进乳腺癌发生和转移的分子机制，以及其在乳腺癌中的作用及功能展开介绍，最后对FSCN1在临床上的价值进行了总结，为FSCN1在乳腺癌领域的研究提供重要的借鉴和参考。
常栋, 刘享享, 刘睿, 孙建伟 . FSCN1在乳腺癌发生发展中的作用及其调控机制[J]. 遗传, 2023 , 45(2) : 115 -127 . DOI: 10.16288/j.yczz.22-346
FSCN1, an actin-bundling protein, is highly expressed in almost all metastatic tumors and is associated with the poor prognosis. In breast cancer FSCN1 is highly expressed in basal-like and triple negative subgroups. There is significant progress in understanding the role of fascin in breast cancer. Studies on FSCN1 in recent years have revealed that FSCN1 not only promotes tumor migration, invasion, metastic colonization, cancer cell self-renewal and drug resistance, but also regulates glucose and lipid metabolism and mitochondrial remodeling in tumor cells. In this review, we focus on the structure and regulatory mechanism of FSCN1 in breast tumorigenesis and metastasis, and discuss the clinical value of FSCN1 with the aim to provide a direction for further research in this field.
Key words： FSCN1; actin bundle; breast cancer; tumorigenesis; tumor progression
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