哺乳动物卵子与早期胚胎中全转录组poly(A)尾研究进展
收稿日期: 2023-03-02
修回日期: 2023-03-13
网络出版日期: 2023-03-14
Research progress on the study of transcriptome-wide poly(A) tails in mammalian oocytes and early embryos
Received date: 2023-03-02
Revised date: 2023-03-13
Online published: 2023-03-14
王文龙, 张春霞 . 哺乳动物卵子与早期胚胎中全转录组poly(A)尾研究进展[J]. 遗传, 2023 , 45(4) : 273 -278 . DOI: 10.16288/j.yczz.23-047
During mammalian oocyte-to-embryo transition, before zygotic genome activation, the transcription in oocytes and embryos is silenced, so the post-transcriptional regulation of mRNA plays an essential role in this process. Poly(A) tail is an important post-transcriptional modification that affects mRNA metabolism and translation efficiency. With the development of sequencing technology and analysis tools, especially the methods based on third-generation sequencing technology, the length and composition of poly(A) tails can be accurately measured, greatly expanding our understanding of poly(A) tails in mammalian early embryonic development. This review focuses on the achievements of poly(A) tail sequencing methods and the research progress of poly(A) tail in regulating oocyte-to-embryo transition, discussing the future applications for the investigation of mammalian early embryonic development and infertility related diseases.
Key words： poly(A) tail; PAIso-seq; early embryogenesis; oocyte-to-embryo transition
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